Glucose Sensor using Liquid-Crystal Droplets Made by Microfluidics

被引：119

作者：

Kim, Jiyeon ^{[1
]}

Khan, Mashooq ^{[1
]}

Park, Soo-Young ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Dept Polymer Sci & Engn, Taegu 702701, South Korea

来源：

ACS APPLIED MATERIALS & INTERFACES | 2013年 / 5卷 / 24期

基金：

新加坡国家研究基金会;

关键词：

biosensor; glucose; GOx; 5CB; droplets; liquid crystal; ORDERING TRANSITIONS; CARBON NANOTUBE; INTERFACES; DEHYDROGENASE; MULTILAYER; ELECTRODE; POLYMERS; PH;

D O I：

10.1021/am404174n

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Micrometer-sized, 4-cyno-4-pentylbiphenyl (5CB) droplets were developed for glucose detection in an aqueous medium by coating with poly(acrylicacid-b-4-cynobiphenyl-4-oxyundecylacrylate) (PAA-b-LCP) at the 5CB/water interface and covalently immobilizing glucose oxidase (GOx) to the PAA chains. This functionalized liquid-crystal (LC) droplet detected glucose from a radial to bipolar configurational change by polarized optical microscopy under crossed polarizers at concentrations as low as 0.03 m/vI and response times of similar to 3 min and showed the selective detection of glucose against galactose. This new and sensitive LC-droplet-based glucose biosensor has the merits of low production cost and easy detection by the naked eye and might be useful for prescreening the glucose level in the human body.

引用

页码：13135 / 13139

页数：5

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