A one-pot direct regioselective iodination of Fischer-Borsche product using periodic acid in PEG-400

被引：13

作者：

Ghom, Monica H. ^{[1
]}

Naykode, Mahavir S. ^{[1
]}

Humne, Vivek T. ^{[1
]}

Lokhande, Pradeep D. ^{[1
]}

机构：

[1] Savitribai Phule Pune Univ, Ctr Adv Studies, Dept Chem, Pune 411007, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 15期

关键词：

Regiocontrolled iodination; Benzocarbazole; PEG-400; Periodic acid; TRANSITION-METAL-COMPLEXES; 1ST TOTAL-SYNTHESIS; ORGANIC-SYNTHESIS; POLYETHYLENE-GLYCOL; CARBAZOLES; IODINE; FUNCTIONALIZATION; INHIBITORS; ANNULATION; UTILITY;

D O I：

10.1016/j.tetlet.2019.03.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free and greener approach for the one-pot direct iodination and dehydrogenation of dihydrobenzo[a]carbazoles has been developed using periodic acid in polyethylene glycol-400 (PEG-400) under mild condition. This method has been proven to be tolerate to a broad range of functional groups, with good to excellent yields include metal-free inexpensive catalyst, easy work-up, benign reaction condition and high regioselectivity. The solvent has been successfully recycled up to 5 times without any loss of activity in an aqueous medium. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：1029 / 1031

页数：3

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