Screening of Russian medicinal and edible plant extracts for angiotensin I-converting enzyme (ACE I) inhibitory activity

被引：8
|
作者：
Ivanov, S. A. [1 ]
Garbuz, S. A. [1 ]
Malfanov, I. L. [1 ]
Ptitsyn, L. R. [1 ]
机构：
[1] Ajinomoto Genet Res Inst, Moscow 117545, Russia
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2013年 / 39卷 / 07期
关键词：
ACE I inhibition; plant extracts; colorimetric assay; RENIN-ANGIOTENSIN; ASSAY;
D O I：
10.1134/S1068162013070054
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The angiotensin I-converting enzyme (ACE I) inhibitory activities of 108 aqueous ethanol extracts obtained from Russian plants were evaluated in vitro. Activity was assessed with a two-stage colorimetric assay using N-[3-(2-furyl)acryloyl]-L-phenylalanyl-glycyl-glycine (FA-PGG) as a substrate and 2,4,6-trinitrobenzenesulfonic acid (TNBS) as a coloring reagent for the enzymatic cleavage product glycylglycine (GG). Extracts from eleven plants, seven of which belong to the family Rosaceae, were found to inhibit ACE I with an IC50 < 0.3 mg/mL. Among these, the Geranium pratense extract was the most active and had an IC50 value of 81 mu g/mL.
引用
收藏
页码：743 / 749
页数：7
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