Permanent and plastic epigenesis in neuroendocrine systems

被引：23
作者：
Auger, Catherine J.
Auger, Anthony P. [1 ]
机构：
[1] Univ Wisconsin, Neurosci Training Program, Madison, WI 53706 USA
来源：
FRONTIERS IN NEUROENDOCRINOLOGY | 2013年 / 34卷 / 03期
关键词：
Epigenetic; MeCP2; Sexual differentiation; Methylation; Vasopressin; Brain; Histones; Coactivators; Sex difference; Steroid hormones; ESTROGEN-RECEPTOR-ALPHA; DNA METHYLATION; SEX-DIFFERENCES; SOCIAL RECOGNITION; BINDING-PROTEIN; PREOPTIC AREA; RETT-SYNDROME; DE-NOVO; BRAIN; EXPRESSION;
D O I：
10.1016/j.yfrne.2013.05.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The emerging area of neuroepigenetics has been linked to numerous mental health illnesses. Importantly, a large portion of what we know about early gene x environment interactions comes from examining epigenetic modifications of neuroendocrine systems. This review will highlight how neuroepigenetic mechanisms during brain development program lasting differences in neuroendocrine systems and how other neuroepigenetic processes remain plastic, even within the adult brain. As epigenetic mechanisms can either be stable or plastic, elucidating the mechanisms involved in reversing these processes could aid in understanding how to reverse pathological epigenetic programming. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：190 / 197
页数：8
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