Synthetic insulin fragment with insulin-like biological activity

被引：0

作者：

Prozorovskiy, VN ^{[1
]}

Maksimova, EM ^{[1
]}

Alekseeva, AE ^{[1
]}

Grebenschikova, OG ^{[1
]}

Abakumova, OY ^{[1
]}

Kutsenko, NG ^{[1
]}

Ivanov, AS ^{[1
]}

Kniazhev, VN ^{[1
]}

Archakov, AI ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Biomed Chem, Moscow 119832, Russia

来源：

BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL | 1999年 / 47卷 / 06期

关键词：

insulin; synthetic peptides; biological activity;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An insulin fragment, representing the C-terminal functionally important site of its molecule and responsible for receptor binding, was synthesized. The fragment consists of two peptides: a dipeptide (A 20-21) and an octapeptide (B 19-26), linked with a disulfide bond (A20 - B19), The biological activity of the newly synthesized fragment relative to insulin was assayed for the influence on glycogenesis and for the ability to stimulate glucose uptake. Comparative tests for the biological activity of the synthesized fragment and of the intact hormone allowed us to conclude that the fragment has insulin-like properties.

引用

页码：957 / 963

页数：7

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