Bimodal effect of glycyrrhizin on macrophage nitric oxide and prostaglandin E2 production

被引：1

作者：

Kato, Takao ^{[2
]}

Horie, Norio ^{[2
,3
]}

Hashimoto, Ken ^{[1
]}

Satoh, Kazue ^{[1
,5
]}

Shimoyama, Tetsuo ^{[2
]}

Kaneko, Tadayoshi ^{[3
,4
]}

Kusama, Kaoru ^{[3
]}

Sakagami, Hiroshi ^{[1
]}

机构：

[1] Meikai Univ, Sch Dent, Div Pharmacol, Dept Diagnost & Therapeut Sci, Sakado, Saitama 3500283, Japan

[2] Saitama Med Ctr, Saitama Med Sch, Dept Oral Surg, Kawagoe, Saitama 3508550, Japan

[3] Meikai Univ, Sch Dent, Div Pathol, Sakado, Saitama 3500283, Japan

[4] Tokyo Med Sch, Dept Oral & Maxillofacial Surg, Shinjuku Ku, Tokyo 1600023, Japan

[5] Showa Univ, Sch Med, Dept Anat, Shinagawa Ku, Tokyo 1428555, Japan

来源：

IN VIVO | 2008年 / 22卷 / 05期

关键词：

glycyrrhizin; Chinese medicine; NO; PGE(2); macrophage;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Glycyrrhizin is a major constituent of Kanzo, a popular herbal medicine used in food and cosmetics. Glycyrrhizin alone did not stimulate nitric oxide (NO) or prostaglandin E-2 (PGE(2)) production by RAW 264.7 cells, but modified lipopolysaccharide (LPS)-stimulated NO and PGE(2) production in a bimodal fashion: it was stimulatory at lower concentrations, whereas it was inhibitory at higher concentrations. Electron-spin resonance spectroscopy showed that glycyrrhizin slightly scavenged the superoxide anion generated by hypoxanthine-xanthine oxidase reaction, but did not scavenge the DPPH and NO radicals. The present study demonstrates the concentration-dependent action of glycyrrhizin on both PGE(2) and NO production by activated macrophages.

引用

页码：583 / 586

页数：4

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