Optimization of antioxidant extraction from edible brown algae Ascophyllum nodosum using response surface methodology

被引:28
作者
Liu, Xin [1 ]
Luo, Guanghong [2 ]
Wang, Lijuan [2 ]
Yuan, Wenqiao [1 ]
机构
[1] North Carolina State Univ, Dept Biol & Agr Engn, Raleigh, NC 27695 USA
[2] Hexi Uniers, Gansu Engn Res Ctr Microalgae, Zhangye 734000, Gansu, Peoples R China
基金
美国食品与农业研究所;
关键词
Antioxidant; Brown algae; Polyphenol; Phlorotannin; RSM; Ascophyllum nodosum; ULTRASOUND-ASSISTED EXTRACTION; PHENOLIC-COMPOUNDS; IN-VITRO; POLYSACCHARIDES; PHLOROTANNINS; SEAWEEDS; L; BIOACTIVITIES; TEMPERATURE; POLYPHENOLS;
D O I
10.1016/j.fbp.2019.01.003
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Brown algae are valuable sources of health-benefiting compounds, such as polyphenols, proteins, and polysaccharides. In the present study, a binary solvent system of ethanol and water was used to obtain crude extracts from edible brown algae Ascophyllum nodosum. The extraction process was optimized using Box-Behnken design and response surface methodology to obtain crude extracts with strong antioxidant activity and high yield. Three variables including solvent-to-solid ratio (30-70 ml/g), ethanol concentration in the solvent system (40-80%), and extraction temperature (20-60 degrees C) were investigated to optimize the extraction process. The condition for maximum antioxidant activity of the crude extract was found at 70 ml/g solvent-to-solid ratio, 80% ethanol concentration, and 20 degrees C extraction temperature, while the condition for the highest crude extract yield was 40 mug solvent-solid-ratio, 44.83% ethanol concentration and 60 degrees C extraction temperature. Under the model-predicted optimal conditions, the predicted antioxidant activity and yield of the crude extract were 74.01 ml/g (1/IC50) and 55.60 mg extract/g-algae, which were in close agreement with the experimental results of 74.05 mug and 53.80 mg extract/g-algae, respectively, suggesting that the models could accurately predict and improve the extraction of antioxidants from A. nodosum. (C) 2019 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:205 / 215
页数:11
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