Tuberous Sclerosis Complex: new criteria for diagnostic work-up and management

被引：26

作者：

Samueli, Sharon ^{[1
]}

Abraham, Klaus ^{[1
]}

Dressler, Anastasia ^{[1
]}

Groeppel, Gudrun ^{[1
]}

Jonak, Constanze ^{[2
]}

Muehlebner, Angelika ^{[1
]}

Prayer, Daniela ^{[3
]}

Reitner, Andreas ^{[4
]}

Feucht, Martha ^{[1
]}

机构：

[1] AKH Wien, Univ Klin Kinder & Jugendheilkunde, Vienna, Austria

[2] AKH Wien, Univ Klin Dermatol, Vienna, Austria

[3] AKH Wien, Univ Klin Neuroradiol, Vienna, Austria

[4] AKH Wien, Univ Klin Ophthalmol, Vienna, Austria

来源：

WIENER KLINISCHE WOCHENSCHRIFT | 2015年 / 127卷 / 15-16期

关键词：

Tuberous sclerosis complex; Everolimus; TOSCA; EPISTOP; mTOR-Inhibitor; RENAL-CELL CARCINOMA; MUTATIONAL ANALYSIS; PEDIATRIC-PATIENTS; EPILEPSY SURGERY; INFANTILE SPASMS; EVEROLIMUS; LYMPHANGIOLEIOMYOMATOSIS; MANIFESTATIONS; CHILDREN; DISEASE;

D O I：

10.1007/s00508-015-0758-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tuberous sclerosis complex (TSC) is a rare genetic multisystem disorder, characterized by predominantly benign tumors in potentially all organ systems. System involvement, severity of clinical symptoms and the response to treatment are age-dependent and heterogeneous. Consequently, the disorder is still not recognized in a considerable number of patients. The diagnostic criteria and the guidelines for surveillance and management of patients with TSC were revised, and the establishment of specialized TSC-centers was strongly recommended during an International Consensus Conference in 2012. TOSCA (TuberOus SClerosis registry to increase disease Awareness), an international patient registry, was started to allow new insights into the causes of different courses. Finally, there are-since the approval of the mTOR inhibitor Everolimus-promising new therapeutic approaches. This review focuses on the various TSC related symptoms occurring at different ages, the novel recommendations for diagnosis and treatment as well as the need for multidisciplinary follow-up.

引用

页码：619 / 630

页数：12

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