Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer

被引：171

作者：

Tommelein, Joke ^{[1
]}

Verset, Laurine ^{[2
]}

Boterberg, Tom ^{[1
]}

Demetter, Pieter ^{[2
]}

Bracke, Marc ^{[1
]}

De Wever, Olivier ^{[1
]}

机构：

[1] Univ Ghent, Lab Expt Canc Res, Dept Radiat Oncol & Expt Canc Res, B-9000 Ghent, Belgium

[2] Univ Libre Bruxelles, Erasme Univ Hosp, Dept Pathol, Brussels, Belgium

来源：

FRONTIERS IN ONCOLOGY | 2015年 / 5卷

关键词：

cancer-associated fibroblasts; pericryptal fibroblasts; colorectal cancer; metastasis; immune cells; MESENCHYMAL STEM-CELLS; STROMAL FIBROBLASTS; COLON-CANCER; TUMOR MICROENVIRONMENT; PERICRYPTAL FIBROBLASTS; EXPRESSION; MYOFIBROBLASTS; ANGIOGENESIS; MARKERS; GROWTH;

D O I：

10.3389/fonc.2015.00063

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) progression and eventually metastasis is directed in many aspects by a circuitous ecosystem consisting of an extracellular matrix scaffold populated by cancer-associated fibroblasts (CAFs), endothelial cells, and diverse immune cells. CAFs are recruited from local tissue-resident fibroblasts or pericryptal fibroblasts and distant fibroblast precursors. CAFs are highly abundant in CRC. In this review, we apply the metastasis-promoting communication of colorectal CAFs to 10 cancer hallmarks described by Hanahan and Weinberg. CAFs influence innate and adaptive tumor immune responses. Using datasets from previously published work, we re-explore the potential messages implicated in this process. Fibroblasts present in metastasis (metastasis-associated fibroblasts) from CRC may have other characteristics and functional roles than CAFs in the primary tumor. Since CAFs connect metastasis-promoting communication, CAF markers are potential prognostic biomarkers. CAFs and their products are possible targets for novel therapeutic strategies.

引用

页数：11

共 65 条

[1]

Adegboyega PA, 2002, ARCH PATHOL LAB MED, V126, P829

[2] LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer [J].

Albrengues, Jean ;

Bourget, Isabelle ;

Pons, Catherine ;

Butet, Vincent ;

Hofman, Paul ;

Tartare-Deckert, Sophie ;

Feral, Chloe C. ;

Meneguzzi, Guerrino ;

Gaggioli, Cedric .

CELL REPORTS, 2014, 7 (05) :1664-1678

[3]

[Anonymous], 2009, CELL COMMUN SIGNAL

[4] Hepatic stellate cell progenitor cells [J].

Asahina, Kinji .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2012, 27 :80-84

[5] Selective Targeting of Interferon γ to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth [J].

Bansal, Ruchi ;

Tomar, Tushar ;

Ostman, Arne ;

Poelstra, Klaas ;

Prakash, Jai .

MOLECULAR CANCER THERAPEUTICS, 2012, 11 (11) :2419-2428

[6] Cancer cells suppress p53 in adjacent fibroblasts [J].

Bar, J. ;

Feniger-Barish, R. ;

Lukashchuk, N. ;

Shaham, H. ;

Moskovits, N. ;

Goldfinger, N. ;

Simansky, D. ;

Perlman, M. ;

Papa, M. ;

Yosepovich, A. ;

Rechavi, G. ;

Rotter, V. ;

Oren, M. .

ONCOGENE, 2009, 28 (06) :933-936

[7] Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation [J].

Calon, Alexandre ;

Espinet, Elisa ;

Palomo-Ponce, Sergio ;

Tauriello, Daniele V. F. ;

Iglesias, Mar ;

Virtudes Cespedes, Maria ;

Sevillano, Marta ;

Nadal, Cristina ;

Jung, Peter ;

Zhang, Xiang H. -F. ;

Byrom, Daniel ;

Riera, Antoni ;

Rossell, David ;

Mangues, Ramon ;

Massague, Joan ;

Sancho, Elena ;

Batlle, Eduard .

CANCER CELL, 2012, 22 (05) :571-584

[8] CD133+colon cancer cells are more interactive with the tumor microenvironment than CD133-cells [J].

Chao, Celia ;

Carmical, J. Russ ;

Ives, Kirk L. ;

Wood, Thomas G. ;

Aronson, Judith F. ;

Gomez, Guillermo A. ;

Djukom, Clarisse D. ;

Hellmich, Mark R. .

LABORATORY INVESTIGATION, 2012, 92 (03) :420-436

[9]

Conti John, 2011, Cancers (Basel), V3, P2160, DOI 10.3390/cancers3022160

[10] Number of pericryptal fibroblasts correlates with density of distinct mast cell phenotypes in the crypt lamina propria of human duodenum: Implications for the homeostasis of villous architecture [J].

Crivellato, Enrico ;

Finato, Nicoletta ;

Isola, Miriam ;

Pandolfi, Maura ;

Ribatti, Domenico ;

Beltrami, Carlo Alberto .

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY, 2006, 288A (06) :593-600

← 1 2 3 4 5 6 7 →