Donor-derived CD19 chimeric antigen receptor T cells

被引：6

作者：

Singh, Nathan ^{[1
]}

Barrett, David M. ^{[2
]}

机构：

[1] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN HEMATOLOGY | 2015年 / 22卷 / 06期

关键词：

chimeric antigen receptors; immunotherapy; T cells; LEUKOCYTE INFUSIONS; HOST-DISEASE; GRAFT; THERAPY; IMMUNOTHERAPY; MALIGNANCIES; TRANSPLANT; EXPRESSION; 4-1BB;

D O I：

10.1097/MOH.0000000000000179

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of reviewAs immunotherapy matures into possible front-line therapy, new approaches are necessary to expand the capacity to treat more patients. Although most technologies for chimeric antigen receptor (CAR) therapies require autologous T cells, off the shelf' sources are highly desired.Recent findingsSources of T cells for modification with CARs include cord blood and either related or unrelated allogeneic donors. Strategies to manipulate these sources focus on reducing the risk of alloreactivity, while maintaining the potential for high function and long persistence associated with successful CAR T-cell therapies.SummaryRecent research implies that manipulating nonautologous T-cell sources can result in well tolerated and effective products, but work remains to determine if these approaches will reach the efficacy of autologous products.

引用

页码：503 / 508

页数：6

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