QT interval prolongation associated with venlafaxine administration

被引：39

作者：

Letsas, K

Korantzopoulos, P ^{[1
]}

Pappas, L

Evangelou, D

Efremidis, M

Kardaras, F

机构：

[1] G Hatzikosta Gen Hosp, Dept Cardiol, Ioannina 45001, Greece

[2] Evangelismos Gen Hosp Athens, Dept Cardiol 2, Athens 10676, Greece

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2006年 / 109卷 / 01期

关键词：

venlafaxine; long QT; side effects; antidepressant drug;

D O I：

10.1016/j.ijcard.2005.03.065

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A significant number of non-antiarrhythmic drugs including psychotropic agents have been shown to prolong cardiac repolarization increasing the risk for torsade de pointes ventricular tachycardia. We briefly describe a 60-year-old woman who admitted to the hospital due to hypertension and mild dyspnea having a prolonged QT interval (QTc: 582 ms). The patient had a known history of depression treated with venlafaxine. The QT interval normalised a few days after cessation of the antidepressant agent. This is the first report of venlafaxine-induced QT interval prolongation. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：116 / 117

页数：2

共 10 条

[1] Conduction disturbances associated with venlafaxine
Combes, A
Peytavin, G
Théron, D
[J]. ANNALS OF INTERNAL MEDICINE, 2001, 134 (02) : 166 - 167
[2] Subchronic antidepressant treatment with venlafaxine or imipramine and effects on blood pressure and heart rate: Assessment by automatic 24-hour monitoring
Grunder, G
Wetzel, H
Schlosser, R
Benkert, O
[J]. PHARMACOPSYCHIATRY, 1996, 29 (02) : 72 - 78
[3] Khalifa M, 1999, J PHARMACOL EXP THER, V291, P280
[4] Clinical and therapeutic aspects of congenital and acquired long QT syndrome
Khan, IA
[J]. AMERICAN JOURNAL OF MEDICINE, 2002, 112 (01) : 58 - 66
[5] Korantzopoulos P, 2004, NEW ENGL J MED, V350, P2618
[6] Panel discussion
Moss, A
de Andrés, F
Roberts, DJ
Tamargo, J
Cavero, I
Luria, X
Llenas, J
Gras, J
Palacios, JM
[J]. DRUG SAFETY, 1999, 21 (Suppl 1) : 81 - 87
[7] Seizures, ventricular tachycardia, and rhabdomyolysis as a result of ingestion of venlafaxine and lamotrigine
Peano, C
Leikin, JB
Hanashiro, P
[J]. ANNALS OF EMERGENCY MEDICINE, 1997, 30 (05) : 704 - 708
[8] Low penetrance in the long-QT syndrome - Clinical impact
Priori, SG
Napolitano, C
Schwartz, PJ
[J]. CIRCULATION, 1999, 99 (04) : 529 - 533
[9] An acute ischaemic event associated with the use of venlafaxine: a case report and proposed pathophysiological mechanisms
Reznik, I
Rosen, Y
Rosen, B
[J]. JOURNAL OF PSYCHOPHARMACOLOGY, 1999, 13 (02) : 193 - 195
[10] Drug therapy: Drug-induced prolongation of the QT interval
Roden, DM
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (10) : 1013 - 1022

← 1 →