Metabolic Makeover for HSCs

被引：30

作者：

Warr, Matthew R. ^{[1
]}

Passegue, Emmanuelle ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div Hematol Oncol, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA

来源：

CELL STEM CELL | 2013年 / 12卷 / 01期

关键词：

HEMATOPOIETIC STEM-CELLS; HYPOXIC NICHE;

D O I：

10.1016/j.stem.2012.12.005

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Hematopoietic stem cells (HSCs) must at times exit quiescence to divide and produce differentiated blood cells. In this issue of Cell Stem Cell, Takubo et al. (2013) and Yu et al. (2013) show that these opposing actions require distinct metabolic programs to meet the changing energy demands of self-renewing HSCs.

引用

页码：1 / 3

页数：3

共 10 条

[1] Rapid Expansion of Human Hematopoietic Stem Cells by Automated Control of Inhibitory Feedback Signaling [J].

Csaszar, Elizabeth ;

Kirouac, Daniel C. ;

Yu, Mei ;

Wang, WeiJia ;

Qiao, Wenlian ;

Cooke, Michael P. ;

Boitano, Anthony E. ;

Ito, Caryn ;

Zandstra, Peter W. .

CELL STEM CELL, 2012, 10 (02) :218-229

[2] Metabolic Plasticity in Stem Cell Homeostasis and Differentiation [J].

Folmes, Clifford D. L. ;

Dzeja, Petras P. ;

Nelson, Timothy J. ;

Terzic, Andre .

CELL STEM CELL, 2012, 11 (05) :596-606

[3] A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance [J].

Ito, Keisuke ;

Carracedo, Arkaitz ;

Weiss, Dror ;

Arai, Fumio ;

Ala, Ugo ;

Avigan, David E. ;

Schafer, Zachary T. ;

Evans, Ronald M. ;

Suda, Toshio ;

Lee, Chih-Hao ;

Pandolfi, Pier Paolo .

NATURE MEDICINE, 2012, 18 (09) :1350-+

[4] Cell cycle regulation in hematopoietic stem cells [J].

Pietras, Eric M. ;

Warr, Matthew R. ;

Passegue, Emmanuelle .

JOURNAL OF CELL BIOLOGY, 2011, 195 (05) :709-720

[5] The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche [J].

Simsek, Tugba ;

Kocabas, Fatih ;

Zheng, Junke ;

DeBerardinis, Ralph J. ;

Mahmoud, Ahmed I. ;

Olson, Eric N. ;

Schneider, Jay W. ;

Zhang, Cheng Cheng ;

Sadek, Hesham A. .

CELL STEM CELL, 2010, 7 (03) :380-390

[6] Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche [J].

Suda, Toshio ;

Takubo, Keiyo ;

Semenza, Gregg L. .

CELL STEM CELL, 2011, 9 (04) :298-310

[7] Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells [J].

Takubo, Keiyo ;

Nagamatsu, Go ;

Kobayashi, Chiharu I. ;

Nakamura-Ishizu, Ayako ;

Kobayashi, Hiroshi ;

Ikeda, Eiji ;

Goda, Nobuhito ;

Rahimi, Yasmeen ;

Johnson, Randall S. ;

Soga, Tomoyoshi ;

Hirao, Atsushi ;

Suematsu, Makoto ;

Suda, Toshio .

CELL STEM CELL, 2013, 12 (01) :49-61

[8] Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells [J].

Takubo, Keiyo ;

Goda, Nobuhito ;

Yamada, Wakako ;

Iriuchishima, Hirono ;

Ikeda, Eiji ;

Kubota, Yoshiaki ;

Shima, Haruko ;

Johnson, Randall S. ;

Hirao, Atsushi ;

Suematsu, Makoto ;

Suda, Toshio .

CELL STEM CELL, 2010, 7 (03) :391-402

[9] Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies [J].

Warr, Matthew R. ;

Pietras, Eric M. ;

Passegue, Emmanuelle .

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 2011, 3 (06) :681-701

[10] Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation [J].

Yu, Wen-Mei ;

Liu, Xia ;

Shen, Jinhua ;

Jovanovic, Olga ;

Pohl, Elena E. ;

Gerson, Stanton L. ;

Finkel, Toren ;

Broxmeyer, Hal E. ;

Qu, Cheng-Kui .

CELL STEM CELL, 2013, 12 (01) :62-74

← 1 →