Prospective cohort study of metabolic risk factors and gastric adenocarcinoma risk in the Metabolic Syndrome and Cancer Project (Me-Can)

被引：47

作者：

Lindkvist, Bjorn ^{[1
,2
]}

Almquist, Martin ^{[3
,4
]}

Bjorge, Tone ^{[5
,6
]}

Stocks, Tanja ^{[7
,8
]}

Borena, Wegene ^{[9
]}

Johansen, Dorthe ^{[10
,11
]}

Hallmans, Goran ^{[12
]}

Engeland, Anders ^{[5
,6
]}

Nagel, Gabriele ^{[13
]}

Jonsson, Hakan ^{[14
]}

Selmer, Randi ^{[6
]}

Diem, Guenter ^{[15
]}

Haggstrom, Christel ^{[7
]}

Tretli, Steinar ^{[16
]}

Stattin, Par ^{[7
]}

Manjer, Jonas ^{[10
,11
,17
]}

机构：

[1] Sahlgrens Univ Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, S-41345 Gothenburg, Sweden

[2] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden

[3] Skane Univ Hosp Lund, Dept Surg, Lund, Sweden

[4] Lund Univ, Lund, Sweden

[5] Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway

[6] Norwegian Inst Publ Hlth, Bergen, Norway

[7] Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden

[8] Copenhagen Univ Hosp, Inst Prevent Med, Copenhagen, Denmark

[9] Innsbruck Med Univ, Dept Med Stat Informat & Hlth Econ, Innsbruck, Austria

[10] Skane Univ Hosp Malmo, Dept Surg, Malmo, Sweden

[11] Lund Univ, Malmo, Sweden

[12] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[13] Univ Ulm, Inst Epidemiol, Ulm, Germany

[14] Umea Univ, Dept Radiat Sci, Umea, Sweden

[15] Agcy Social & Prevent Med, Bregenz, Austria

[16] Canc Registry Norway, Inst Populat Based Canc Res, Oslo, Norway

[17] Malmo Univ Hosp, Malmo Diet & Canc Study, Malmo, Sweden

来源：

CANCER CAUSES & CONTROL | 2013年 / 24卷 / 01期

基金：

瑞典研究理事会;

关键词：

Gastric adenocarcinoma; Epidemiology; Cohort study; Metabolic syndrome; CONOR; POPULATION-BASED COHORT; BODY-MASS INDEX; DIABETES-MELLITUS; REGRESSION DILUTION; FOLLOW-UP; ESOPHAGUS; MORTALITY; GLUCOSE; OBESITY; CARDIA;

D O I：

10.1007/s10552-012-0096-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Little is known about the association between the metabolic syndrome (MetS) and the risk of gastric adenocarcinoma. The aim of this study was to investigate whether metabolic risk factors, together or combined, were associated with the risk of gastric adenocarcinoma. The Metabolic Syndrome and Cancer Project (Me-Can) is a pooling of prospective cohorts in Austria, Norway, and Sweden with information on blood pressure, lipids, glucose, and BMI available in 578,700 individuals. Cox proportional hazards analysis was used to calculate hazard ratio (HR) of gastric adenocarcinoma using metabolic risk factors categorized into quintiles and transformed into z-scores (with mean = 0 and SD = 1). The standardized sum of all z-scores created a composite MetS score. In total, 1,210 incident cases of gastric adenocarcinoma were identified. Glucose was significantly associated with the risk of gastric adenocarcinoma [calibrated HR 1.58 (1.14-2.20) per one unit increment in z-score] in women. There was a statistically significant association between triglycerides and risk of gastric adenocarcinoma per mmol increment in triglycerides [HR 1.20 (1.06-1.36) per mmol] but not for the adjusted z-score in women. There were no significant association between any metabolic factors and gastric cancer among men. The composite MetS score was associated with the risk of gastric adenocarcinoma in women [HR 1.18 (1.00-1.38) per one unit increment in z-score] but not in men. Glucose and high levels of the composite MetS score were associated with an increased risk of gastric adenocarcinoma in women but not in men.

引用

页码：107 / 116

页数：10

共 57 条

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