A new biflavone glucoside from the roots of Stellera chamaejasme

被引：5

作者：

Chen Wei ^{[1
]}

Luo Xiao-Hua ^{[1
]}

Wang Zhuo ^{[1
]}

Zhang Ying-Ying ^{[1
]}

Liu Li-Ping ^{[1
]}

Wang Hong-Bing ^{[1
]}

机构：

[1] Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2015年 / 13卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Stellera chamaejasme; Thymelaeaceae; Biflavone glucoside; Cytotoxicity; PISCICIDAL CONSTITUENTS; BIFLAVANONES; FLAVONOIDS; DITERPENES; COUMARINS;

D O I：

10.1016/S1875-5364(15)30050-9

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The present study investigated the chemical constituents of the roots of Stellera chamaejasme (Thymelaeaceae). One new biflavone glucoside (1), along with other thirteen known compounds (2-14), was isolated by repeated column chromatographic methods and their structures were elucidated on the basis of spectral analyses. The cytotoxic activities of selected compounds were evaluated against four human cancer cell lines (A549, BEL-7402, HCT-116, and MDA-MB-231) by the SRB assay method. Compound 9 showed remarkable cytotoxicity against BEL-7402 with IC50 value being 0.65 mu g.mL(-1); compounds 7, 8, and 12 exhibited significant cytotoxic activity against A549 with IC50 values being 2.38, 1.57, and 2.35 mu g.mL(-1), respectively.

引用

页码：550 / 553

页数：4

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