Glucosylated caffeoylquinic acid derivatives from the flower buds of Lonicera japonica

被引：51

作者：

Yu, Yang ^{[1
,2
]}

Jiang, Zhibo ^{[1
,2
]}

Song, Weixia ^{[1
,2
]}

Yang, Yongchun ^{[1
,2
]}

Li, Yuhuan ^{[2
,3
]}

Jiang, Jiandong ^{[1
,2
,3
]}

Shi, Jiangong ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2015年 / 5卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Flower buds; Loincera japonica; Caprifoliaceae; Glucosylated caffeoylquinic acid; Coxsackie virus B3; TRITERPENOID SAPONINS; COUPLED SECOIRIDOIDS; QUINIC ACID; GLUCOSIDES; GLYCOSIDES; ELUCIDATION;

D O I：

10.1016/j.apsb.2015.01.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Three new glucosylated caffeoylquinic acid isomers (1-3), along with six known compounds, have been isolated from an aqueous extract of the flower buds of Lonicera japonica. Structures of the new compounds were determined by spectroscopic and chemical methods as (-)-4-O-(4-O-beta-D-glucopyranosylcaffeoyl)quinic acid (-)-3-O-(4-O-beta-D-glucopyranosylcaffeoyl)quinic acid (2), and (-)-5-O-(4-O-beta-D-glucopyranosylcaffeoyl)quinic acid (3), respectively. In the preliminary in vitro assays, two known compounds methyl caffeate and 2'-O-methyladenosine showed inhibitory activity against Coxsackie virus B3 with IC50 values of 3.70 mu mol/L and 6.41 mu mol/L and SI values of 7.8 and 12.1, respectively. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

引用

页码：210 / 214

页数：5

共 33 条

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