Sensitivity testing of the Seizure Severity Questionnaire (SSQ)

被引：12
作者：
Borghs, Simon [1 ]
de la Loge, Christine [2 ]
Brabant, Yves
Cramer, Joyce
机构：
[1] UCB Pharma, Slough SL1 3WE, Berks, England
[2] UCB Pharma, Brussels, Belgium
来源：
EPILEPSY & BEHAVIOR | 2014年 / 31卷
关键词：
Seizure severity; Seizure Severity Questionnaire (SSQ); Sensitivity; Patient-reported outcome; Epilepsy; PARTIAL-ONSET SEIZURES; RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; ADJUNCTIVE LACOSAMIDE; EPILEPSY; SCALE; EFFICACY; THERAPY; SAFETY;
D O I：
10.1016/j.yebeh.2013.10.010
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The sensitivity of the Seizure Severity Questionnaire (SSQ) was evaluated using pooled data from open-label extensions of two clinical trials in patients with partial-onset seizures. The SSQ includes questions relating to frequency and helpfulness of warning signs as well as frequency, severity, and bothersomeness of ictal and postictal effects. Differences between mean change from baseline for each SSQ item for responders and non-responders were described and compared between patients solely with complex partial seizures (CPSs: responders, n = 166; nonresponders, n = 127) and those solely with secondarily generalized partial seizures (SGPSs: responders, n = 26; nonresponders, n = 24) at baseline. Seizure Severity Questionnaire total score and individual SSQ items related to ictal movement, consciousness, bothersomeness of postictal effects, and frequency of postictal emotional effects showed differentiation between seizure type responders. These data provide further validation of the SSQ by demonstrating its sensitivity in describing treatment effects. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：281 / 285
页数：5
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