Stress Flips a Chromatin Switch to Wake Up Latent Virus

被引：8

作者：

Avgousti, Daphne C. ^{[1
,2
]}

Weitzman, Matthew D. ^{[1
,2
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Div Canc Pathobiol, Philadelphia, PA 19104 USA

来源：

CELL HOST & MICROBE | 2015年 / 18卷 / 06期

关键词：

D O I：

10.1016/j.chom.2015.11.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Stress-induced reactivation of latent herpesviruses requires disabling of repression, but the mechanism for converting silenced chromatin into an active state is unknown. In this issue of Cell Host & Microbe, Cliffe et al. (2015) suggest a methyl/phospho switch on histone H3 overcomes repression to facilitate reactivation of latent herpes simplex virus type 1 (HSV-1).

引用

页码：639 / 641

页数：3

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