Molecular mechanisms of protective roles of isoflavones against chemicals-induced liver injuries

被引：19

作者：

Alipour, Mohammad Reza ^{[1
,2
]}

Karimi-Sales, Elham ^{[1
,2
]}

机构：

[1] Tabriz Univ Med Sci, TB & Lung Dis Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Fac Med, Dept Physiol, Tabriz, Iran

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2020年 / 329卷

关键词：

Isoflavones; Alcoholic liver disease; Drug-induced liver injury; Toxicant-induced liver injury; CCL4-INDUCED HEPATIC-FIBROSIS; OXIDATIVE STRESS; CHRONIC ALCOHOL; GENE-EXPRESSION; PUERARIN; GENISTEIN; PHYTOESTROGENS; ACETAMINOPHEN; HEPATOTOXICITY; INFLAMMATION;

D O I：

10.1016/j.cbi.2020.109213

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytoestrogens are plant-derived substances with a similar structure to 17-beta-estradiol, which have protective roles in estrogen-dependent diseases. Isoflavones, the most well-known subgroup of phytoestrogens, play pro-tective roles against chemicals-induced liver injuries through several molecular mechanisms. Hepatoprotective effects of isoflavones are, partly, associated with their antioxidant, anti-inflammatory, immunomodulatory, and anti-fibrotic properties. Besides, isoflavones can reduce gut-derived endotoxins, accelerate alcohol metabolism, stimulate detoxification of hepatotoxic chemicals, suppress the bioactivation of these chemicals, inhibit hepatocytes apoptosis, and restore autophagy activity during chemicals-induced liver diseases. This review provides a summary of the molecular mechanisms underlying the hepatoprotective effects of isoflavones. It seems that further studies are needed to investigate the hepatoprotective potential of isoflavones in patients with different stages of chemicals-induced liver injuries.

引用

页数：9

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