Triple Antithrombotic Therapy for Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention

被引：6

作者：

Kerneis, Mathieu ^{[1
]}

Talib, Usama ^{[1
]}

Nafee, Tarek ^{[1
]}

Daaboul, Yazan ^{[1
]}

Pahlavani, Seyedmandi ^{[1
]}

Pitliya, Anmol ^{[1
]}

Furgan, M. M. ^{[1
]}

Datta, Sudarshana ^{[1
]}

Kazmi, Hassan A. ^{[1
]}

Younes, Ahmed ^{[1
]}

Gibson, C. Michael ^{[1
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Cardiovasc Div,PERFUSE Study Grp, Boston, MA USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2018年 / 60卷 / 4-5期

关键词：

Percutaneous coronary intervention; Atrial fibrillation; Rivaroxaban; Novel oral anticoagulation; Review; DUAL ANTIPLATELET THERAPY; ACUTE MYOCARDIAL-INFARCTION; ELUTING STENT IMPLANTATION; LONG-TERM ANTICOAGULATION; VITAMIN-K ANTAGONISTS; FACTOR XA INHIBITOR; DOUBLE-BLIND; ORAL ANTICOAGULATION; CONCOMITANT USE; PLUS ASPIRIN;

D O I：

10.1016/j.pcad.2018.01.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dual antiplatelet therapy (DAPT) has been the cornerstone of antithrombotic management for patients undergoing percutaneous coronary intervention (PCI). However, approximately 10% of these patients have concomitant atrial fibrillation (AF) and require chronic oral anticoagulant (OAC) in addition to DA'. This traditional "triple therapy" has been associated with a three to four-fold increased risk of bleeding. The safety of non-vitamin K OAC (NOAC)-based strategies, using a NOAC plus a P2Y(12) inhibitor, has been compared to vitamin K antagonist (VKA)-based triple therapy in the PIONEER AF-PCI and REDUAL PCI randomized trials, both of which have demonstrated that NOAC-based strategies are safer and provide an attractive alternative to VKA-based triple therapy among AF patients who undergo PCI. This article reviews the rationale, evidence, and recent evaluation of triple antithrombotic therapy among AF patients undergoing PCI. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：524 / 530

页数：7

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