Palladium-Catalyzed Coupling of Hydroxylamines with Aryl Bromides, Chlorides, and Iodides

被引：43
|
作者：
Porzelle, Achim [1 ]
Woodrow, Michael D. [2 ]
Tomkinson, Nicholas C. O. [1 ]
机构：
[1] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, S Glam, Wales
[2] GlaxoSmithKline Med Res Ctr, Immunoinflammat Ctr Excellence Drug Discovery, Stevenage SG1 2NY, Herts, England
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 01期
基金：
英国工程与自然科学研究理事会;
关键词：
HIGHLY-ACTIVE CATALYST; ONE-POT SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; AMINATION; ALPHA; CYCLOADDITION; REDUCTION; LIGANDS; HALIDES;
D O I：
10.1021/ol8025022
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The bis-pyrazole phosphine ligand BippyPhos is effective for the palladium-catalyzed cross-coupling of hydroxylamines with aryl bromides, chlorides, and iodides. Reactions proceed smoothly at 80 degrees C in toluene in the presence Of Cs2CO3 to give synthetically versatile N-arylhydroxylamine products In good to excellent yield.
引用
收藏
页码：233 / 236
页数：4
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