Reproduction, Fat Metabolism, and Life Span: What Is the Connection?

被引：240

作者：

Hansen, Malene ^{[1
]}

Flatt, Thomas ^{[2
,3
]}

Aguilaniu, Hugo ^{[4
,5
,6
]}

机构：

[1] Sanford Burnham Med Res Inst, Del E Webb Neurosci Aging & Stem Cell Res Ctr, Dev & Aging Program, La Jolla, CA 92037 USA

[2] Vetmeduni Vienna, Inst Populat Genet, A-1210 Vienna, Austria

[3] Wissensch Kolleg Berlin, Inst Adv Study, D-14193 Berlin, Germany

[4] Ecole Normale Super Lyon, F-69342 Lyon, France

[5] CNRS, F-69342 Lyon, France

[6] Univ Lyon 1, Mol Biol Cell Lab, UMR5239, F-69342 Lyon, France

来源：

CELL METABOLISM | 2013年 / 17卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

GERMLINE STEM-CELLS; GENE-EXPRESSION; ADIPOSE-TISSUE; C; ELEGANS; DROSOPHILA-MELANOGASTER; STARVATION RESISTANCE; STRESS RESISTANCE; HORMONE-RECEPTOR; SOMATIC TISSUES; DAUER FORMATION;

D O I：

10.1016/j.cmet.2012.12.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reduced reproduction is associated with increased fat storage and prolonged life span in multiple organisms, but the underlying regulatory mechanisms remain poorly understood. Recent studies in several species provide evidence that reproduction, fat metabolism, and longevity are directly coupled. For instance, germline removal in the nematode Caenorhabditis elegans promotes longevity in part by modulating lipid metabolism through effects on fatty acid desaturation, lipolysis, and autophagy. Here, we review these recent studies and discuss the mechanisms by which reproduction modulates fat metabolism and life span. Elucidating the relationship between these processes could contribute to our understanding of age-related diseases including metabolic disorders.

引用

页码：10 / 19

页数：10

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