Hematological manifestations of celiac disease

被引:51
作者
Baydoun, Atallah [1 ]
Maakaron, Joseph E. [1 ]
Halawi, Houssam [1 ]
Abou Rahal, Jihane [1 ]
Taher, Ali T. [1 ]
机构
[1] Amer Univ Beirut, Med Ctr, Hematol Oncol Div, Dept Internal Med, Beirut 11072020, Lebanon
关键词
anemia; celiac disease; neutropenia; thrombocythemia; thrombocytopenia; ACTIVATABLE FIBRINOLYSIS INHIBITOR; LYMPH-NODE CAVITATION; GLUTEN-FREE DIET; T-CELL LYMPHOMA; REFRACTORY SPRUE; IMMUNOGLOBULIN-A; RISK; DEFICIENCY; PREVALENCE; ANEMIA;
D O I
10.3109/00365521.2012.706828
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Celiac disease, an autoimmune disease once thought to be uncommon, is now being increasingly identified. Our improved diagnostic modalities have allowed us to diagnose more and more patients with atypical symptoms who improve on gluten-free diet (GFD). We discuss here the latest findings regarding the various hematological manifestations of celiac disease and their management. Anemia remains the most common hematological manifestation of celiac disease due to many mechanisms, and can be the sole presenting symptom. Other manifestations include thrombocytosis and thrombocythemia, leukopenia, thromboembolism, increased bleeding tendency, IgA deficiency, splenic dysfunction, and lymphoma. The diagnosis of celiac disease should always be kept in mind when a patient presents with unexplained and isolated hematological finding. Once diagnosed, patients should adhere to GFD and be educated about the potential complications of this disease. We herein present an algorithm for adequate management and follow-up.
引用
收藏
页码:1401 / 1411
页数:11
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