The impact of probiotics and prebiotics on the immune system

被引：235
作者：
Klaenhammer, Todd R. [1 ]
Kleerebezem, Michiel [2 ]
Kopp, Matthias Volkmar [3 ]
Rescigno, Maria [4 ]
机构：
[1] N Carolina State Univ, Dept Food Bioproc & Nutr Sci, Raleigh, NC 27695 USA
[2] Wageningen Univ, Host Microbe Interact Grp, NL-6708 WD Wageningen, Netherlands
[3] Med Univ Lubeck, Childrens Hosp, Dept Pediat Pulmonol & Allergy, UKSH, D-23538 Lubeck, Germany
[4] European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy
来源：
NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 10期
基金：
欧洲研究理事会;
关键词：
PLACEBO-CONTROLLED TRIAL; LACTOBACILLUS-RHAMNOSUS GG; RANDOMIZED CONTROLLED-TRIAL; 1ST; 6; MONTHS; IRRITABLE-BOWEL-SYNDROME; T-REGULATORY CELLS; DOUBLE-BLIND; LIPOTEICHOIC ACID; ATOPIC-DERMATITIS; EXPERIMENTAL COLITIS;
D O I：
10.1038/nri3312
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Probiotics and prebiotics are increasingly being added to foodstuffs with claims of health benefits. Probiotics are live microorganisms that are thought to have beneficial effects on the host, whereas prebiotics are ingredients that stimulate the growth and/or function of beneficial intestinal microorganisms. But can these products directly modulate immune function and influence inflammatory diseases? Here, Nature Reviews Immunology asks four experts to discuss these issues and provide their thoughts on the future application of probiotics as a disease therapy.
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页码：728 / 734
页数：8
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