Biomarker counseling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment: A European Alzheimer's disease consortium survey

被引：21

作者：

Frederiksen, Kristian S. ^{[1
]}

Nielsen, Thomas R. ^{[1
]}

Appollonio, Ildebrando ^{[2
,3
]}

Andersen, Birgitte Bo ^{[1
]}

Riverol, Mario ^{[4
]}

Boada, Merce ^{[5
,6
,7
]}

Ceccaldi, Mathieu ^{[8
,9
]}

Dubois, Bruno ^{[10
,11
]}

Engelborghs, Sebastiaan ^{[12
,13
,14
,15
,16
]}

Froelich, Lutz ^{[17
]}

Hausner, Lucrezia ^{[17
]}

Gabelle, Audrey ^{[18
]}

Gabryelewicz, Tomasz ^{[19
]}

Grimmer, Timo ^{[20
]}

Hanseeuw, Bernard ^{[21
]}

Hort, Jakub ^{[22
]}

Hugon, Jacques ^{[23
]}

Jelic, Vesna ^{[24
]}

Koivisto, Anne ^{[25
,26
]}

Kramberger, Milica G. ^{[27
]}

Lebouvier, Thibaud ^{[28
]}

Lleo, Alberto ^{[29
]}

de Mendonca, Alexandre ^{[30
]}

Nobili, Flavio ^{[31
,32
]}

Ousset, Pierre-Jean ^{[33
]}

Perneczky, Robert ^{[34
,35
,36
,37
]}

Olde Rikkert, Marcel ^{[38
]}

Robinson, David ^{[39
]}

Rouaud, Olivier ^{[40
]}

Sanchez, Elisabet ^{[41
]}

Santana, Isabel ^{[42
,43
]}

Scarmeas, Nikolaos ^{[44
,45
]}

Sheardova, Katerina ^{[46
]}

Sloan, Stephanie ^{[47
]}

Spiru, Luiza ^{[48
,49
]}

Stefanova, Elka ^{[50
]}

Traykov, Latchezar ^{[51
]}

Yener, Gorsev ^{[52
,53
]}

Waldemar, Gunhild ^{[1
]}

机构：

[1] Univ Copenhagen, Danish Dementia Res Ctr, Dept Neurol, Rigshosp, Copenhagen, Denmark

[2] Univ Milano Bicocca, Sch Med & Surg, Milan, Italy

[3] Univ Milano Bicocca, Milan Ctr Neurosci NeuroMI, Milan, Italy

[4] Univ Navarra, Clin Univ Navarra, Dept Neurol, Madrid, Spain

[5] Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr, Fundacio ACE, Barcelona, Spain

[6] Univ Int Catalunya, Memory Clin, Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain

[7] Inst Salud Carlos III, Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain

[8] CHU Timone, APHM, Dept Neurol & Neuropsychol, Marseille, France

[9] Aix Marseille Univ, INSERM, Inst Neurosci Syst, Marseille, France

[10] Salpetriere Univ Hosp, Alzheimer Res Ctr IM2A, Paris, France

[11] Sorbonne Univ, Salpetriere Univ Hosp, AP HP, Dept Neurol, Paris, France

[12] Inst Born Bunge, Reference Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium

[13] Univ Antwerp, Antwerp, Belgium

[14] UZ Brussel, Dept Neurol, Brussels, Belgium

[15] UZ Brussel, Ctr Neurosci, Brussels, Belgium

[16] Vrije Univ Brussel VUB, Brussels, Belgium

[17] Heidelberg Univ, Cent Inst Mental Hlth, Dept Geriatr Psychiat, Mannheim, Germany

[18] Univ Montpellier, Memory Resources & Res Ctr, Dept Neurol, Gui Chauliac Hosp,Montpellier Univ Hosp, Montpellier, France

[19] Mossakowski Med Res Ctr PAN, Dept Neurodegenerat Disorders, Warsaw, Poland

[20] Tech Univ Munich, Sch Med, Klinikum Rechts Isar, Dept Psychiat & Psychotherapy, Munich, Germany

[21] Catholic Univ Louvain, Inst Neurosci, Dept Neurol, Clin Univ St Luc, Brussels, Belgium

[22] Charles Univ Prague, Memory Clin, Dept Neurol, Fac Med 2,Motol Univ Hosp, Prague, Czech Republic

[23] Univ Paris, Lariboisiere Hosp Paris, Ctr Cognit Neurol, Paris, France

[24] Karolinska Univ Hosp Huddinge, Clin Cognit Disorders, Theme Aging, Stockholm, Sweden

[25] Univ Eastern Finland, Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland

[26] Univ Helsinki, Helsinki Univ Hosp, Dept Neurosci & Geriatr, Helsinki, Finland

[27] Univ Med Ctr Ljubljana, Ctr Cognit Impairments, Ljubljana, Slovenia

[28] Lille 2 Univ Hlth & Law, Pole Neurol, Lille, France

[29] Hosp Santa Creu & Sant Pau, Neurol Dept, Barcelona, Spain

[30] Univ Lisbon, Fac Med, Lisbon, Portugal

[31] Univ Genoa, Dept Neurosci, DINOGMI, Genoa, Italy

[32] IRCCS Osped Policlin San Martino, Genoa, Italy

[33] Toulouse Univ Hosp, Clin Res Ctr, Memory Clin, Toulouse, France

[34] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany

[35] German Ctr Neurodegenerat Disorders DZNE, Munich, Germany

[36] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[37] Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol AGE Res Unit, London, England

[38] Radboud Univ Nijmegen, Radboudumc Alzheimer Ctr, Dept Geriatr, Med Ctr, Nijmegen, Netherlands

[39] St James Hosp, Memory Clin, Dublin, Ireland

[40] Vaud Univ Hosp, Leenaards Memory Ctr, Dept Clin Neurosci, Lausanne, Switzerland

[41] Hosp Univ Ramon & Cajal, Serv Geriatria, Madrid, Spain

[42] Ctr Hosp & Univ Coimbra, Neurol Dept, Coimbra, Portugal

[43] Univ Coimbra, Fac Med, Coimbra, Portugal

[44] Natl & Kapodistrian Univ Athens, Aiginition Univ Hosp, Dept Neurol 1, Athens, Greece

[45] Columbia Univ, Dept Neurol, Med Ctr, New York, NY USA

[46] St Annes Univ Hosp, Memory Ctr ICRC, Int Clin Res Ctr, Brno, Czech Republic

[47] Ninewells Hosp, Neuroprogress Disorders & Dementia Network, Dundee, Scotland

[48] Carol Davila Univ Med & Pharm, Geriatr Gerontol & Old Age Psychiat Alzheimer Uni, Clin Dept, Bucharest, Romania

[49] Ana Aslan Int Fdn, Excellence Memory Clin & Longev Med, Bucharest, Romania

[50] Univ Belgrade, Fac Med, Clin Ctr Serbia, Neurol Clin, Belgrade, Serbia

来源：

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY | 2021年 / 36卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; biomarker counseling; biomarkers; dementia; diagnosis; diagnostic disclosure; mild cognitive impairment; survey; DEMENTIA; PREVALENCE; ATTITUDES; RECOMMENDATIONS; CRITERIA;

D O I：

10.1002/gps.5427

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objectives Mild cognitive impairment (MCI) is associated with an increased risk of further cognitive decline, partly depending on demographics and biomarker status. The aim of the present study was to survey the clinical practices of physicians in terms of biomarker counseling, management, and follow-up in European expert centers diagnosing patients with MCI. Methods An online email survey was distributed to physicians affiliated with European Alzheimer's disease Consortium centers (Northern Europe: 10 centers; Eastern and Central Europe: 9 centers; and Southern Europe: 15 centers) with questions on attitudes toward biomarkers and biomarker counseling in MCI and dementia. This included postbiomarker counseling and the process of diagnostic disclosure of MCI, as well as treatment and follow-up in MCI. Results The response rate for the survey was 80.9% (34 of 42 centers) across 20 countries. A large majority of physicians had access to biomarkers and found them useful. Pre- and postbiomarker counseling varied across centers, as did practices for referral to support groups and advice on preventive strategies. Less than half reported discussing driving and advance care planning with patients with MCI. Conclusions The variability in clinical practices across centers calls for better biomarker counseling and better training to improve communication skills. Future initiatives should address the importance of communicating preventive strategies and advance planning.

引用

页码：324 / 333

页数：10

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