Fuzzy Tandem Repeats Containing p53 Response Elements May Define Species-Specific p53 Target Genes

被引：18

作者：

Simeonova, Iva ^{[1
,2
,3
]}

Lejour, Vincent ^{[1
,2
,3
]}

Bardot, Boris ^{[1
,2
,3
]}

Bouarich-Bourimi, Rachida ^{[1
,2
,3
]}

Morin, Aurelie ^{[1
,2
,3
]}

Fang, Ming ^{[1
,2
,3
]}

Charbonnier, Laure ^{[1
,2
,3
]}

Toledo, Franck ^{[1
,2
,3
]}

机构：

[1] Ctr Rech, Inst Curie, Paris, France

[2] Univ Paris 06, Paris, France

[3] CNRS, UMR 3244, Paris, France

来源：

PLOS GENETICS | 2012年 / 8卷 / 06期

关键词：

EMBRYONIC STEM-CELLS; TRANSPOSABLE ELEMENTS; RETINAL DEVELOPMENT; MOUSE MODEL; RETINOBLASTOMA; RB; PATHWAY; MICE; SUPPRESSOR; CARCINOMA;

D O I：

10.1371/journal.pgen.1002731

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Evolutionary forces that shape regulatory networks remain poorly understood. In mammals, the Rb pathway is a classic example of species-specific gene regulation, as a germline mutation in one Rb allele promotes retinoblastoma in humans, but not in mice. Here we show that p53 transactivates the Retinoblastoma-like 2 (Rbl2) gene to produce p130 in murine, but not human, cells. We found intronic fuzzy tandem repeats containing perfect p53 response elements to be important for this regulation. We next identified two other murine genes regulated by p53 via fuzzy tandem repeats: Ncoa1 and Klhl26. The repeats are poorly conserved in evolution, and the p53-dependent regulation of the murine genes is lost in humans. Our results indicate a role for the rapid evolution of tandem repeats in shaping differences in p53 regulatory networks between mammalian species.

引用

页数：11

共 42 条

[1] Differentiated horizontal Interneurons clonally expand to form metastatic retinoblastoma in mice [J].

Ajioka, Itsuki ;

Martins, Rodrigo A. P. ;

Bayazitov, Ildar T. ;

Donovan, Stacy ;

Johnson, Dianna A. ;

Frase, Sharon ;

Cicero, Samantha A. ;

Boyd, Kelli ;

Zakharenko, Stanislav S. ;

Dyer, Michael A. .

CELL, 2007, 131 (02) :378-390

[2] Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[3] Further characterisation of the p53 responsive element - Identification of new candidate genes for trans-activation by p53 [J].

Bourdon, JC ;

DeguinChambon, V ;

Lelong, JC ;

Dessen, P ;

May, P ;

Debuire, B ;

May, E .

ONCOGENE, 1997, 14 (01) :85-94

[4] Evolution of the mammalian transcription factor binding repertoire via transposable elements [J].

Bourque, Guillaume ;

Leong, Bernard ;

Vega, Vinsensius B. ;

Chen, Xi ;

Lee, Yen Ling ;

Srinivasan, Kandhadayar G. ;

Chew, Joon-Lin ;

Ruan, Yijun ;

Wei, Chia-Lin ;

Ng, Huck Hui ;

Liu, Edison T. .

GENOME RESEARCH, 2008, 18 (11) :1752-1762

[5] Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma [J].

Chen, D ;

Livne-Bar, I ;

Vanderluit, JL ;

Slack, RS ;

Agochiya, M ;

Bremner, R .

CANCER CELL, 2004, 5 (06) :539-551

[6] REQUIREMENT FOR A FUNCTIONAL RB-1 GENE IN MURINE DEVELOPMENT [J].

CLARKE, AR ;

MAANDAG, ER ;

VANROON, M ;

VANDERLUGT, NMT ;

VANDERVALK, M ;

HOOPER, ML ;

BERNS, A ;

RIELE, HT .

NATURE, 1992, 359 (6393) :328-330

[7] A polymorphic microsatellite that mediates induction of PIG3 by p53 [J].

Contente, A ;

Dittmer, A ;

Koch, MC ;

Roth, J ;

Dobbelstein, M .

NATURE GENETICS, 2002, 30 (03) :315-320

[8] Compensation by tumor suppressor genes during retinal development in mice and humans [J].

Donovan, Stacy L. ;

Schweers, Brett ;

Martins, Rodrigo ;

Johnson, Dianna ;

Dyer, Michael A. .

BMC BIOLOGY, 2006, 4 (1)

[9] Use of preclinical models to improve treatment of retinoblastoma [J].

Dyer, MA ;

Rodriguez-Galindo, C ;

Wilson, MW .

PLOS MEDICINE, 2005, 2 (10) :971-976

[10] DEFINITION OF A CONSENSUS BINDING-SITE FOR P53 [J].

ELDEIRY, WS ;

KERN, SE ;

PIETENPOL, JA ;

KINZLER, KW ;

VOGELSTEIN, B .

NATURE GENETICS, 1992, 1 (01) :45-49

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