Short-term outcome and attainment of secondary prevention goals in patients with acute coronary syndrome-Results from the countrywide TARGET study

被引：31

作者：

Andrikopoulos, G. ^{[1
]}

Tzeis, S. ^{[1
]}

Nikas, N. ^{[2
]}

Richter, D. ^{[3
]}

Pipilis, A. ^{[4
]}

Gotsis, A. ^{[5
]}

Tsaknakis, T. ^{[6
]}

Kartalis, A. ^{[7
]}

Kitsiou, A. ^{[8
]}

Toli, K. ^{[9
]}

Mantas, I. ^{[9
]}

Olympios, C. ^{[10
]}

Pras, A. ^{[11
]}

Lampropoulos, S. ^{[12
]}

Oikonomou, K. ^{[13
]}

Pappas, C. ^{[15
]}

Kranidis, A. ^{[14
]}

Anastasiou-Nana, M. ^{[15
]}

Triposkiadis, F. ^{[16
]}

Goudevenos, I. ^{[17
]}

Theodorakis, G. ^{[1
]}

Vardas, P. ^{[18
,19
]}

机构：

[1] Henry Dunant Hosp Athens, Athens, Greece

[2] AstraZeneca SA, Med Dept Athens, Athens, Greece

[3] Euroclin Hosp Athens, Athens, Greece

[4] Hygeia Hosp Athens, Athens, Greece

[5] Gen Hosp Komotini, Komotini, Greece

[6] Achilopouleio Gen Hosp Volos, Volos, Greece

[7] Chios Gen Hosp, Chios, Greece

[8] Sismanoglio Gen Hosp, Sismanoglio, Greece

[9] Gen Hosp Halkida, Halkida, Greece

[10] Thriassio Gen Hosp, Thriassio, Greece

[11] Gen Hosp Chania, Khania, Greece

[12] Bodosakeio Gen Hosp Ptolemaida, Ptolemaida, Greece

[13] Gen Hosp Edessa, Edessa, Greece

[14] Western Attica Gen Hosp, Athens, Greece

[15] Attikon Univ Hosp, Athens, Greece

[16] Univ Hosp Larissa, Larisa, Greece

[17] Univ Hosp Ioannina, Ioannina, Greece

[18] Univ Hosp Herakl, Iraklion, Greece

[19] Herakl Univ Hosp, Dept Cardiol, Iraklion 71110, Crete, Greece

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2013年 / 168卷 / 02期

关键词：

Acute coronary syndrome; Secondary prevention; Outcome; EUROPEAN-SOCIETY; MEDICAL THERAPY; HEART-DISEASE; MANAGEMENT; ASSOCIATION; GUIDELINES; MORTALITY; DISCHARGE; RISK;

D O I：

10.1016/j.ijcard.2012.10.049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/objectives: Acute coronary syndromes (ACS) continue to pose a significant medical and socioeconomic burden worldwide. Optimal management strategy aims to improve short and long-term outcome. The present study aims to assess short-term outcome of real-world ACS patients and evaluate the achievement rate of secondary prevention goals. Methods: The TARGET study is an observational study enrolling 418 consecutive ACS patients from 17 centers countrywide (78.0% males, 63.9 +/- 12.9 years). After the in-hospital phase, patients were followed for 6 months. In total, 366 patients were included in the prospective phase of the study. At the end of the follow-up, mortality, major adverse cardiovascular events (MACE), prescription pattern of cardiovascular medications, lipid levels, adherence rate to treatment and behavioral recommendations were measured. Results: The overall mortality was 4.8% and the rate of MACE was 17.5%. At 6 months, a significantly lower proportion of patients received antiplatelet agents and statins as compared to hospital discharge. At the end of the follow-up, 87.7% of patients remained on statin treatment, yet only 18.2% of patients had LDL cholesterol levels less than 70 mg/dL. The adherence pattern to lifestyle and dietary recommendations remained low (66.2% quit smoking, 55.8% and 81.3% followed physical activity and dietary recommendations respectively). Conclusion: Despite the low rate of mortality and MACE occurrence rate in this countrywide observational study, the attainment rate of secondary prevention goals is relatively poor. Improvement interventions focusing in these gaps of optimal care provision are expected to have a favorable impact on the prognosis of real world ACS patients. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：922 / 927

页数：6

共 25 条

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