Role of interleukin-6 gene polymorphisms in the development of prostate cancer

被引：9

作者：

Chen, C. H. ^{[1
]}

Gong, M. ^{[1
]}

Yi, Q. T. ^{[1
]}

Guo, J. H. ^{[1
]}

机构：

[1] Fudan Univ, Pudong Med Ctr, Dept Urol, Shanghai Pudong Hosp, Shanghai 200433, Peoples R China

来源：

GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 04期

关键词：

Interleukin-6; Polymorphism; Prostate cancer; PROMOTER; RISK;

D O I：

10.4238/2015.October.26.34

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the role of two functional polymorphisms, IL6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer. A total of 212 consecutive primary prostate cancer patients and 236 control subjects were recruited between May 2012 and May 2014. The IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796) polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of IL-6174G> C (rs1800795) and IL-6-572C>G (rs1800796) met the Hardy-Weinberg equilibrium in the controls. Unconditional logistic regression analyses showed that the GG genotype of IL-6-572C>G (rs1800796) was associated with an elevated risk of prostate cancer compared with the CC genotype, and the OR (95% CI) for the GG genotype was 2.06 (1.11-3.87). In conclusion, we suggest that the IL-6-572C>G (rs1800796) gene polymorphism influences the development of prostate cancer.

引用

页码：13370 / 13374

页数：5

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