Cost-effectiveness of a pediatric dengue vaccine

被引：117

作者：

Shepard, DS ^{[1
]}

Suaya, JA ^{[1
]}

Halstead, SB ^{[1
]}

Nathan, MB ^{[1
]}

Gubler, DJ ^{[1
]}

Mahoney, RT ^{[1
]}

Wang, DNC ^{[1
]}

Meltzer, MI ^{[1
]}

机构：

[1] Brandeis Univ, Heller Sch, Schneider Inst Hlth Policy, Waltham, MA 02454 USA

来源：

VACCINE | 2004年 / 22卷 / 9-10期

关键词：

dengue; vaccine; vaccination; cost-effectiveness; disability-adjusted life year; DALY; developing countries; cost; Southeast Asia;

D O I：

10.1016/j.vaccine.2003.09.019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To ascertain the economic feasibility of a pediatric tetravalent dengue vaccine, we developed and calibrated a cost-effectiveness model of vaccinating children at 15 months in Southeast (SE) Asia using a societal perspective. We assumed that full immunization would require two doses at prices of US$ 0.50 and US$ 10 per dose in the public and private sectors, respectively. The gross cost per 1000 population (of all ages) of the vaccination program would be US$ 154. Due to projected savings in dengue treatment, the net cost per capita would be only US$ 17 (89% below the gross cost). The cost per disability adjusted life year (DALY) saved by a pediatric vaccine would be US$ 50, making the potential vaccine highly cost-effective. Eventually, vaccination may be able to replace environmental control as a strategy for dengue prevention and be cost saving. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1275 / 1280

页数：6

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