Vitamin D and type 2 diabetes mellitus

被引：10

作者：

Cangoz, S. ^{[1
]}

Chang, Y. -Y. ^{[1
]}

Chempakaseril, S. J. ^{[1
]}

Guduru, R. C. ^{[1
]}

Huynh, L. M. ^{[1
]}

John, J. S. ^{[1
]}

John, S. T.

Joseph, M. E. ^{[1
]}

Judge, R. ^{[1
]}

Kimmey, R. ^{[1
]}

Kudratov, K. ^{[1
]}

Lee, P. J. ^{[1
]}

Madhani, I. C. ^{[1
]}

Shim, P. J. ^{[1
]}

Singh, S. ^{[1
]}

Ruchalski, C. ^{[1
]}

Raffa, R. B. ^{[1
]}

机构：

[1] Temple Univ, Sch Pharm, Philadelphia, PA 19122 USA

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2013年 / 38卷 / 02期

关键词：

25-hydroxyvitamin D; diabetes; evidence-based medicine; hypovitaminosis; vitamin D; BETA-CELL FUNCTION; 25-HYDROXYVITAMIN D; D DEFICIENCY; PANCREATIC-SECRETION; D SUPPLEMENTATION; RISK; PREVENTION; POPULATION; MORTALITY; PREGNANCY;

D O I：

10.1111/jcpt.12026

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

What is known and Objective: The deleterious effect of vitamin D deficiency on bone health has long been known. More recent studies suggest a deleterious effect of low vitamin D (hypovitaminosis D) on general health. And specific studies propose an association between hypovitaminosis D and the aetiology and progression of type 2 diabetes (T2DM). Given a commonly assumed lack of toxicity of vitamin D, routine measurement of plasma vitamin D and supplementation is rapidly becoming accepted general practice. Comment: Authoritative practice guidelines have raised the level of vitamin D that is to be considered minimal for optimum health. This recommendation was based on a wealth of information and definitive evidence for skeletal benefits of vitamin D, but there was a lack of compelling evidence that hypovitaminosis D is causally related to extra-skeletal health outcomes such as diabetes. Hence, vitamin D supplementation for the purpose of achieving a level consistent with good health is evidence based, but measurement and supplementation for the purpose of preventing or treating T2DM is not. What is new and Conclusion: Although the maintenance of adequate vitamin D levels is desirable for all patients, we conclude that routine measurement of vitamin D level in every patient or initiating high-dose supplementation for the purpose of preventing or treating T2DM is not evidence based.

引用

页码：81 / 84

页数：4

共 48 条

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