Infection and immunity with the RH strain of Toxoplasma gondii in rats and mice

被引：47

作者：

Dubey, JP ^{[1
]}

Shen, SK ^{[1
]}

Kwok, OCH ^{[1
]}

Frenkel, JK ^{[1
]}

机构：

[1] USDA ARS, BARC E, Inst Livestock & Poultry Sci, Parasite Biol & Epidemiol Lab, Beltsville, MD 20705 USA

来源：

JOURNAL OF PARASITOLOGY | 1999年 / 85卷 / 04期

关键词：

D O I：

10.2307/3285739

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Infection and immunity to toxoplasmosis induced by the RH strain of Toxoplasma gondii was compared in Sprague-Dawley (SD) and Wistar rats and in outbred Swiss Webster mice. All rats injected with up to 1,000,000 RH-strain tachyzoites remained clinically normal, whereas mice injected with only 1 Live tachyzoite died of acute toxoplasmosis. Rats could be infected with 1 tachyzoite of the RH strain as shown by antibody development and by bioassay in mice. However, after 8 days, RH-strain organisms were recovered only inconsistently from SD and Wistar rat brains. Contrary to a report of sterile immunity to T. gondii infection in rats after immunization with live RH tachyzoites, we found infection immunity after challenge with the VEG strain. Toxoplasma gondii tissue cysts of the VEG strain could be recovered from most SD and Wistar rats, first injected with live RH-strain tachyzoites and then challenged with oocysts of the VEG strain. Our RH strain, and probably many others, passed for 50+ yr as tachyzoites has lost not only the capacity to form oocysts, but also shows a marked reduction or absence of tissue cyst (bradyzoites) formation.

引用

页码：657 / 662

页数：6

共 26 条

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