Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in women

被引：66
作者：
Woodson, K
Flood, A
Green, L
Tangrea, JA
Hanson, J
Cash, B
Schatzkin, A
Schoenfeld, P
机构：
[1] NCI, Canc Prevent Studies Branch, Canc Res Ctr, NIH, Bethesda, MD 20892 USA
[2] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
[3] Univ Minnesota, Div Epidemiol, Minneapolis, MN 55455 USA
[4] Natl Naval Med Res Inst, Bethesda, MD USA
[5] Vet Affairs Med Ctr, Ctr Excellence Hlth Outcomes Res, Ann Arbor, MI USA
[6] Univ Michigan, Sch Med, Div Gastroenterol, Ann Arbor, MI USA
来源：
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2004年 / 96卷 / 05期
关键词：
D O I：
10.1093/jnci/djh042
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Loss of imprinting (LOI) of insulin-like growth factor-II (IGF-II) may be an inherited epigenetic trait that is polymorphic in the population, and its presence may predispose an individual to the development of colorectal cancer. We evaluated the association between LOI of IGF-II in normal colonic mucosal samples and adenomas in women participating in a colonoscopy screening study. Among 40 participants, 11 (27.5%) had LOI of IGF-II in their normal colonic mucosal tissue. After adjusting for body mass index and family history of colorectal cancer, LOI status was associated with a fivefold increased risk of adenoma formation (odds ratio = 5.2, 95% confidence interval = 1.0 to 26.7). On average, IGF-II expression was more than threefold higher among women with LOI of IGF-II than among women with normal imprinting status. Our findings support the hypothesis that LOI of IGF-II is an epigenetic trait polymorphic in the population and suggest that LOI of IGF-II may play a role in colorectal cancer. These findings are intriguing and need to be confirmed in larger studies.
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收藏
页码：407 / 410
页数：4
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