The nitric oxide-endothelin-1 connection

被引：101
作者：
Alonso, D [1 ]
Radomski, MW [1 ]
机构：
[1] Univ Texas, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA
来源：
HEART FAILURE REVIEWS | 2003年 / 8卷 / 01期
基金：
加拿大健康研究院;
关键词：
nitric oxide; endothelin; vascular tone; cardiovascular system; receptor antagonist; heart failure;
D O I：
10.1023/A:1022155206928
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Nitric oxide (NO) and endothelin-1 (ET-1) are endothelium-derived mediators that play important roles in vascular homeostasis. This review is focused on the role and reciprocal interactions between NO and ET-1 in health and diseases associated with endothelium dysfunction. We will also discuss the clinical significance of NO donors and drugs that antagonize ET receptors.
引用
收藏
页码：107 / 115
页数：9
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