Does ionizing radiation influence Alzheimer's disease risk?

被引：41

作者：

Begum, Nasrin ^{[1
,2
]}

Wang, Bing ^{[1
]}

Mori, Masahiko ^{[1
]}

Vares, Guillaume ^{[1
]}

机构：

[1] Natl Inst Radiol Sci, Inage Ku, Chiba 2638555, Japan

[2] Rajshahi Med Coll, Ctr Nucl Med & Ultrasound, Rajshahi, Bangladesh

来源：

JOURNAL OF RADIATION RESEARCH | 2012年 / 53卷 / 06期

关键词：

Alzheimer's disease; aging; dementia; cognitive effects; ionizing radiation; ATOMIC-BOMB SURVIVORS; OXIDATIVE DAMAGE; GENE-EXPRESSION; DNA-DAMAGE; MITOCHONDRIAL DYSFUNCTION; MICROARRAY ANALYSIS; ADULT NEUROGENESIS; COGNITIVE FUNCTION; INDUCED APOPTOSIS; COMMON VARIANTS;

D O I：

10.1093/jrr/rrs036

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alzheimer's disease (AD) is a human neurodegenerative disease, and its global prevalence is predicted to increase dramatically in the following decades. There is mounting evidence describing the effects of ionizing radiation (IR) on the brain, suggesting that exposure to IR might ultimately favor the development of AD. Therefore better understanding the possible connections between exposure to IR and AD pathogenesis is of utmost importance. In this review, recent developments in the research on the biological and cognitive effects of IR in the brain will be explored. Because AD is largely an age-related pathology, the effects of IR on ageing will be investigated.

引用

页码：815 / 822

页数：8

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