Chemistry of 3-Oxo-N-(pyridin-2-yl)butanamide and Related Compounds

被引：12

作者：

Fadda, Ahmed A. ^{[1
]}

Abdel-Galil, Ebrahim ^{[1
]}

Elattar, Khaled M. ^{[1
,2
]}

机构：

[1] Mansoura Univ, Fac Sci, Dept Chem, Mansoura 35516, Egypt

[2] Sert Univ, Fac Educ, Dept Chem, Sert, Libya

来源：

SYNTHETIC COMMUNICATIONS | 2015年 / 45卷 / 18期

关键词：

Biological importance; 3-oxo-N-(pyridin-2-yl)butanamide; pyridines; reactions; synthesis; TERT-BUTYL ACETOTHIOACETATE; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; PYRIDINE-DERIVATIVES; SUBSTITUTED PYRIDINES; BETA-KETOTHIOESTERS; PRACTICAL SYNTHESIS; ANTITUMOR-ACTIVITY; METAL-COMPLEXES; SERIES;

D O I：

10.1080/00397911.2015.1048369

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review highlights the methods used for the synthesis of 3-oxo-N-(pyridin-2-yl)butanamide compounds. The reactivity and synthetic importance are investigated. In this context, recent progress in the synthesis and use of 3-oxo-N-(pyridin-2-yl)butanamide as precursors for heterocyclic compounds is reviewed. The synthetic routes for preparation of 3-oxo-N-(pyridin-2-yl)butanamide are based on the reaction of diketene with aromatic primary amine and reaction of 2-aminopyridine with -keto-t-butylthioester or ethylacetoacetate. The bibliography includes 73 references.

引用

页码：2053 / 2082

页数：30

共 76 条

[1] Synthesis, spectral characterization and in vitro antimicrobial activity of some new azopyridine derivatives [J].

Abuo-Melha, Hanaa ;

Fadda, A. A. .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2012, 89 :123-128

[2] ULTRAVIOLET SPECTRA AND STRUCTURES OF THE PYRIDO [1,2-A]PYRIMIDONES [J].

ADAMS, R ;

PACHTER, IJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (21) :5491-5497

[3] STRUCTURE OF THE 2-PYRIDONE AND ALPHA-BROMOACRYLIC ACID ADDUCT AND ITS DERIVATIVES [J].

ADAMS, R ;

PACHTER, IJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (19) :4906-4909

[4]

Ali M. I., 1989, EGYPT J CHEM, V30, P357

[5]

ALI MA, 1974, COORDIN CHEM REV, V13, P101

[6] Certain azomethines in the pyrimidazolone series [J].

Allen, CFH ;

Van Allan, J ;

Wilson, CV .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1944, 66 :1805-1810

[7]

[Anonymous], 2009, INTER J DRUG DISCOV

[8]

ATTIA A, 1982, PHARMAZIE, V37, P551

[9]

Attla A.M, 1999, NUCLEOSIDES NUCLEOTI, V18, P2301

[10] Synthesis and antidiabetic activity of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines and thieno[2,3-b]pyridines [J].

Bahekar, Rajesh H. ;

Jain, Mukul R. ;

Jadav, Pradip A. ;

Prajapati, Vijay M. ;

Patel, Dipam N. ;

Gupta, Arun A. ;

Sharma, Ajay ;

Tom, Robby ;

Bandyopadhya, Debdutta ;

Modi, Honey ;

Patel, Pankaj R. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (21) :6782-6795

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