Photosensitivity syndrome brings to light a new transcription-coupled DNA repair cofactor

被引：23

作者：

Cleaver, James E. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA

来源：

NATURE GENETICS | 2012年 / 44卷 / 05期

关键词：

COCKAYNE-SYNDROME; EXCISION-REPAIR; NUCLEOTIDE; PROTEIN; HIF-1;

D O I：

10.1038/ng.2255

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Three teams have applied whole-exome and proteome methods to identify a new cofactor of human RNA polymerase II that is required for the recovery of transcription on damaged templates. The identification of this new factor raises questions about the causal relationships between molecular mechanisms of transcription regulation and excision repair and developmental and neurological disease and nonmalignant skin photosensitivity.

引用

页码：477 / 478

页数：2

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