Migratory potential of transplantable neural tumor cell lines

被引：2

作者：

Bayer, TA

Thier, M

Roeb, E

Breuer, B

Weggen, S

Wiestler, OD

Weis, J

机构：

[1] Univ Bonn, Med Ctr, Dept Psychiat, D-53105 Bonn, Germany

[2] Univ Bonn, Med Ctr, Dept Neuropathol, D-53105 Bonn, Germany

[3] Rhein Westfal TH Aachen, Inst Neuropathol, D-52057 Aachen, Germany

[4] Rhein Westfal TH Aachen, Dept Med, D-52057 Aachen, Germany

[5] Univ Bern, Inst Pathol, Div Neuropathol, CH-3010 Bern, Switzerland

来源：

ACTA NEUROPATHOLOGICA | 1999年 / 97卷 / 06期

关键词：

transplantation; migration; rat brain; matrix-metalloproteinases; neural tumor cell lines;

D O I：

10.1007/s004010051036

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Experimentally induced primitive neuroectodermal tumor (PNET) cell lines were transplanted into neonatal and adult rat brain and examined neuropathologically for their tumorigenic potential. Both cell lines showed a striking migratory behavior in both neonatal and adult brain. Migration of tumor cells was found in host brain parenchyma, along white matter tracts and associated with CSF pathways. These neural tumor cell lines provide a valuable tool for the development of strategies against strongly migrating neural tumors.

引用

页码：607 / 612

页数：6

共 41 条

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Amberger VR, 1998, CANCER RES, V58, P149

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