Dietary Emulsifiers Exacerbate Food Allergy and Colonic Type 2 Immune Response through Microbiota Modulation

被引：8

作者：

Harusato, Akihito ^{[1
]}

Chassaing, Benoit ^{[2
]}

Dauriat, Charlene J. G. ^{[2
]}

Ushiroda, Chihiro ^{[3
]}

Seo, Wooseok ^{[4
]}

Itoh, Yoshito ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Gastroenterol, Kajii Cho 465,Kamigyo Ku, Kyoto 6028566, Japan

[2] Univ Paris Cite, Team Mucosal Microbiota Chron Inflammatory Dis, INSERM U1016, CNRS UMR8104, 24 Rue Faubourg St Jacques Paris, F-75014 Paris, France

[3] Fujita Hlth Univ, Sch Med, Dept Clin Nutr, Toyoake 4701192, Japan

[4] Nagoya Univ, Dept Immunol, Grad Sch Med, Nagoya 4640813, Japan

来源：

NUTRIENTS | 2022年 / 14卷 / 23期

关键词：

food allergy; dietary emulsifiers; microbiota; INFLAMMATION;

D O I：

10.3390/nu14234983

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The significant increase in food allergy incidence is correlated with dietary changes in modernized countries. Here, we investigated the impact of dietary emulsifiers on food allergy by employing an experimental murine model. Mice were exposed to drinking water containing 1.0% carboxymethylcellulose (CMC) or Polysorbate-80 (P80) for 12 weeks, a treatment that was previously demonstrated to induce significant alterations in microbiota composition and function leading to chronic intestinal inflammation and metabolic abnormalities. Subsequently, the ovalbumin food allergy model was applied and characterized. As a result, we observed that dietary emulsifiers, especially P80, significantly exacerbated food allergy symptoms, with increased OVA-specific IgE induction and accelerated type 2 cytokine expressions, such as IL-4, IL-5, and IL-13, in the colon. Administration of an antibiotic regimen completely reversed the emulsifier-induced exacerbated susceptibility to food allergy, suggesting a critical role played by the intestinal microbiota in food allergy and type 2 immune responses.

引用

页数：13

共 32 条

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