Mechanism of cisplatin resistance in human urothelial carcinoma cells

被引：15

作者：

Yu, Hui-Min ^{[2
]}

Wang, Tsing-Cheng ^{[1
]}

机构：

[1] Acad Sinica, Inst Cellular & Organism Biol, Taipei 115, Taiwan

[2] Natl Def Med Ctr, Grad Inst Life Sci, Taipei 114, Taiwan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2012年 / 50卷 / 05期

关键词：

Urothelial carcinoma; Cisplatin; Bcl-2; HO-1; p16; BLADDER-CANCER CELLS; CELLULAR ACCUMULATION; HEME OXYGENASE-1; DOWN-REGULATION; INDUCED APOPTOSIS; ACQUIRED-RESISTANCE; HIGH CYTOTOXICITY; DRUG-RESISTANCE; PROXIMAL TUBULE; OVARIAN-CANCER;

D O I：

10.1016/j.fct.2012.01.040

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

An isogenic pair of cisplatin-susceptible (NTUB1) and -resistant (NTUB1/P) human urothelial carcinoma cell lines was used to elucidate the mechanism of cisplatin resistance. The significantly lower intracellular platinum (IP) concentration, which resulted from the decreased cisplatin uptake, was found in NTUB1/P cells. The enhancement of IP concentration did not increase the susceptibility of NTUB1/P cells to cisplatin treatment. The reduction of IP concentration as well was unable to enhance the cisplatin-resistance in susceptible NTUB1 cells. This indicated that reduction of IF concentration was not the account for the development of cisplatin resistance here. Instead, the over expression of anti-apoptotic Bcl-2, anti-oxidative heme oxygenase-1 (HO-1) and cell cycle regulator p16INK4 seemed to be more important for the gaining of cisplatin in these human urothelial carcinoma cell. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1226 / 1237

页数：12

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