The emerging roles of circular RNAs in regulating the fate of stem cells

被引：5
作者：
Zhuang, Ziyao [1 ]
Jia, Lingfei [2 ,3 ]
Li, Weiran [1 ]
Zheng, Yunfei [1 ]
机构：
[1] Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, 22 Zhongguancun Ave South, Beijing 100081, Peoples R China
[2] Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
[3] Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2021年 / 476卷 / 01期
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
Circular RNA; Stem cells; Cell differentiation; Cell proliferation; Apoptosis; OSTEOGENIC DIFFERENTIATION; PROMOTES DIFFERENTIATION; BINDING PROTEIN; GROWTH-FACTOR; BETA-CATENIN; PROLIFERATION; IDENTIFICATION; EXPRESSION; MYOBLASTS; REVEALS;
D O I：
10.1007/s11010-020-03900-w
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Circular RNAs(circRNAs) are a large family of RNAs shaping covalently closed ring-like molecules and have become a hotspot with thousands of newly published studies. Stem cells are undifferentiated cells and have great potential in medical treatment due to their self-renewal ability and differentiation capacity. Abundant researches have unveiled that circRNAs have unique expression profile during the differentiation of stem cells and could serve as promising biomarkers of these cells. There are key circRNAs relevant to the differentiation, proliferation, and apoptosis of stem cells with certain mechanisms such as sponging miRNAs, interacting with proteins, and interfering mRNA translation. Moreover, several circRNAs have joined in the interplay between stem cells and lymphocytes. Our review will shed lights on the emerging roles of circRNAs in regulating the fate of diverse stem cells.
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收藏
页码：231 / 246
页数：16
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