The Role of Statins in the Setting of HIV Infection

被引：32

作者：

Eckard, Allison Ross ^{[1
,2
]}

McComsey, Grace A. ^{[3
]}

机构：

[1] Med Univ S Carolina, Dept Pediat, Div Infect Dis, Charleston, SC 29425 USA

[2] Med Univ S Carolina, Dept Med, Div Infect Dis, Charleston, SC 29425 USA

[3] Case Western Reserve Univ, Cleveland, OH 44106 USA

来源：

CURRENT HIV/AIDS REPORTS | 2015年 / 12卷 / 03期

基金：

美国国家卫生研究院;

关键词：

HIV; Statins; Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors; Cardiovascular disease; Inflammation; Immune activation; C-REACTIVE PROTEIN; RECEIVING ANTIRETROVIRAL THERAPY; COA REDUCTASE INHIBITORS; ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROME; VASCULAR INFLAMMATION; MONOCYTE ACTIVATION; DIABETES-MELLITUS; CHOLESTEROL GOALS; PLASMA-LIPIDS;

D O I：

10.1007/s11904-015-0273-9

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

HIV-infected individuals are at an increased risk of cardiovascular disease (CVD) and other HIV-related co-morbidities. This is due in part to dyslipidemia associated with antiretroviral therapy and increased inflammation and immune activation from chronic HIV infection. Statins not only have potent lipid-lowering properties but are also anti-inflammatory and immunomodulators. Studies suggest that statin therapy in the HIV-infected population may decrease the risk of CVD and other non-AIDS-defining co-morbidities. This review summarizes the recent literature on statin use in the HIV setting.

引用

页码：305 / 312

页数：8

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