共 59 条
Early-life stress and vulnerability for disease in later life
被引:13
作者:
Entringer, Sonja
[1
]
Buss, Claudia
[1
]
Heim, Christine
[1
]
机构:
[1] Charite Univ Med Berlin, Inst Med Psychol, Luisenstr 57, D-10117 Berlin, Germany
关键词:
Developmental programming;
Childhood trauma;
Prenatal stress;
Transgenerational transmission;
Epigenetics;
ADVERSE CHILDHOOD EXPERIENCES;
PRENATAL PSYCHOSOCIAL STRESS;
MAJOR DEPRESSION;
DNA METHYLATION;
INTERGENERATIONAL CONTINUITY;
ENVIRONMENT INTERACTIONS;
DEHYDROGENASE TYPE-2;
MATERNAL STRESS;
HPA AXIS;
MALTREATMENT;
D O I:
10.1007/s00103-016-2436-2
中图分类号:
R1 [预防医学、卫生学];
学科分类号:
1004 ;
120402 ;
摘要:
Background. The rapidly growing research field of developmental programming of health and disease risk investigates the early life origins of individual vulnerability for common, complex disorders that confer a major burden of disease. Objectives. The present article introduces the concept of developmental programming of disease vulnerability and summarizes studies on the mental and physical health consequences of exposure to childhood trauma and prenatal stress. Biological mechanisms that mediate disease risk after early life stress are discussed. The possibility of transgenerational transmission of effects of childhood trauma in exposed women to their children and potential mechanisms of this transmission are also presented. Conclusion. A substantial number of studies show associations between early life stress and risk for mental and somatic diseases in later life. The underlying mechanisms are currently being studied at the molecular and epigenetic level. Potentially, these findings will allow unprecedented opportunities to improve the precision of current clinical diagnostic tools and the success of interventions. However, there is currently a lack of translation of research findings related to developmental programming to clinical applications.
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页码:1255 / 1261
页数:7
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