Recent achievements to combat bacterial resistance.

被引：42
作者：
Silveira, Gustavo Pozza
Nome, Faruk
Gesser, Jose Carlos
Sa, Marcus Mandolesi
Terenzi, Hernan
机构：
[1] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Dept Bioquim, BR-88040900 Florianopolis, SC, Brazil
来源：
QUIMICA NOVA | 2006年 / 29卷 / 04期
关键词：
gram-positive bacteria; bacterial resistance; vancomycin;
D O I：
10.1590/S0100-40422006000400037
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This article provides an overview on the recent achievements to combat Gram-positive bacteria and the mechanisms related to antimicrobial activity and bacterial resistance. Selected synthetic methodologies to access structurally diverse bioactive compounds are presented in order to emphasize the most important substances currently developed to overcome multiresistant strains. The main properties of vancomycin and related glycopeptide antibiotics are also discussed as a background to understanding the design of new chemotherapeutic agents.
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收藏
页码：844 / 855
页数：12
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