One Pot Regioselective Synthesis of a Small Library of Dibenzo[b,f][1,4]thiazepin-11(10H)-ones via Smiles Rearrangement

被引：14
作者：
Zhao, Yongmei [1 ]
Dai, Qiaoling [1 ]
Chen, Zhi [1 ]
Zhang, Qihui [1 ]
Bai, Yongcheng [1 ]
Ma, Chen [1 ]
机构：
[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
来源：
ACS COMBINATORIAL SCIENCE | 2013年 / 15卷 / 02期
基金：
中国国家自然科学基金;
关键词：
metal-free process; benzoic-fused seven-membered lactams; Smiles rearrangement; DERIVATIVES; INHIBITORS; SERIES; AGENTS;
D O I：
10.1021/co300139s
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A facile and efficient method has been developed for the synthesis of a small library of dibenzo[b,f][1,4]thiazepin-11(10H)-ones via Smiles rearrangement. Compounds were obtained in excellent isolated yields (70%-92%) under metal-free conditions. More specifically, this transition metal-free process relates to an environmentally friendly, economical, and efficient method for preparing benzoic-fused seven-membered lactams.
引用
收藏
页码：130 / 134
页数：5
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