Structural and Functional Diversity Among Amyloid Proteins: Agents of Disease, Building Blocks of Biology, and Implications for Molecular Engineering

被引:30
作者
Bleem, Alissa [1 ]
Daggett, Valerie [1 ]
机构
[1] Univ Washington, Dept Bioengn, Box 355013, Seattle, WA 98195 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
amyloid; protein misfolding; toxic oligomers; functional amyloid; amyloid materials; A-BETA OLIGOMER; INDUCED CONFORMATIONAL CONVERSION; X-RAY-DIFFRACTION; ALZHEIMERS-DISEASE; CEREBROSPINAL-FLUID; MISFOLDING DISEASES; ALPHA-SYNUCLEIN; EARLY STEPS; STREPTOMYCES-COELICOLOR; SEQUENCE DETERMINANTS;
D O I
10.1002/bit.26059
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Amyloids have long been associated with protein dysfunction and neurodegenerative diseases, but recent research has demonstrated that some organisms utilize the unique properties of the amyloid fold to create functional structures with important roles in biological processes. Additionally, new engineering approaches have taken advantage of amyloid structures for implementation in a wide variety of materials and devices. In this review, the role of amyloid in human disease is discussed and compared to the functional amyloids, which serve a largely structural purpose. We then consider the use of amyloid constructs in engineering applications, including their utility as building blocks for synthetic biology and molecular engineering. (C) 2016 Wiley Periodicals, Inc.
引用
收藏
页码:7 / 20
页数:14
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