Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance

被引：126
作者：
Fujinami, Aya [1 ]
Ohta, Kiyoe [2 ]
Obayashi, Hiroshi [3 ]
Fukui, Michiaki [4 ]
Hasegawa, Goji [4 ]
Nakamura, Naoto [4 ]
Kozai, Hana [5 ]
Imai, Saeko [5 ]
Ohta, Mitsuhiro [1 ,2 ]
机构：
[1] Kobe Pharmaceut Univ, Dept Med Biochem, Higashinada Ku, Kobe, Hyogo 6588558, Japan
[2] Natl Utano Hosp, Natl Hosp Org, Clin Res Ctr, Kyoto 6168255, Japan
[3] Inst Bioresponse Informat, Kyoto 6128016, Japan
[4] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto 6020841, Japan
[5] Osaka Prefecture Univ, Fac Comprehens Rehabil, Dept Clin Nutr, Osaka 5835855, Japan
来源：
CLINICAL BIOCHEMISTRY | 2008年 / 41卷 / 10-11期
关键词：
brain-derived neurotrophic factor; type; 2; diabetes; insulin; adiponectin; leptin;
D O I：
10.1016/j.clinbiochem.2008.03.003
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objectives: The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance. Design and methods: We studied 112 patients with T2DM and 80 age- and gender-matched control subjects. Results: Serum BDNF levels were significantly lower in patients with T2DM compared to control subjects (15.5 +/- 5.2 ng/mL vs. 20.0 +/- 7.3 ng/mL, P<0.01). In patients with T2DM, BDNF levels were significantly higher in females than in males (P<0.01). In the female patients, BDNF was positively related to immunoreactive insulin (IRI) (rho=0.458, P<0.05) and HOMA-R (rho=0.444, P<0.05). Stepwise multiple regression analysis showed a significant relationship between BDNF and IRI (F=5.294, P<0.05) in female patients with diabetes. Conclusions: These findings suggest that BDNF may contribute to glucose metabolism. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：812 / 817
页数：6
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