A Highly Active PN3 Manganese Pincer Complex Performing N-Alkylation of Amines under Mild Conditions

被引：63
作者：
Homberg, Leonard [1 ]
Roller, Alexander [2 ]
Hultzsch, Kai C. [1 ]
机构：
[1] Univ Vienna, Fac Chem, Inst Chem Catalysis, Wahringer Str 38, A-1090 Vienna, Austria
[2] Univ Vienna, Fac Chem, Xray Struct Anal Ctr, Wahringer Str 42, A-1090 Vienna, Austria
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 09期
关键词：
CATALYZED ALPHA-ALKYLATION; BORROWING HYDROGEN; PRIMARY ALCOHOLS; DEHYDROGENATION; RUTHENIUM; METHANOL; H-2; METHYLATION; ALDIMINES; AMINATION;
D O I：
10.1021/acs.orglett.9b00832
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly active Mn(I) catalyst based on a nonsymmetric PN3-ligand scaffold for the N-alkylation of amines with alcohols utilizing the borrowing hydrogen methodology is reported. A broad range of anilines and the more challenging aliphatic amines were alkylated with primary and secondary alcohols. Moreover, the combination of low catalyst loadings and mild reaction conditions provides high efficiency for this atom-economic transformation.
引用
收藏
页码：3142 / 3147
页数：6
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