Synthesis of I-131 derivatives of indolealkylamines for brain mapping

被引：0
作者：
Sintas, JA [1 ]
Vitale, AA [1 ]
机构：
[1] UNIV BUENOS AIRES,FAC CIENCIAS EXACTAS & NAT,DEPT QUIM ORGAN,PROPLAME CONICET,RA-1428 BUENOS AIRES,DF,ARGENTINA
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1997年 / 39卷 / 08期
关键词：
2-[I-131]-iodo-N; N-dimethyltryptamine; 2-[I-131]-iodo-N-methyltryptamine; 2-[I-131]-iodo-5-methoxy-N; 2-[I-131]-iodo-5-hydroxy-N; N-dimethyltryptamine); 2-[I-131]-iodo-tryptamine; 2-[I-131]-melatonine;
D O I：
10.1002/(SICI)1099-1344(199708)39:8<677::AID-JLCR9>3.0.CO;2-G
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis and spectral properties of new radioiodinated indolealkylamines like 2-[I-131]-iodo-N,N-dimethyltryptamine, 2-[I-131]-iodo-N-methyltryptamine, 2-[I-131]-iodo-5-methoxy-N,N-dimethyltryptamine, 2-[I-131]-iodo-5-hydroxy-N,N-dimethyltryptamine (2-[I-131]-iodo-bufotenine), and 2-[I-131]-iodo-tryptamine and the known 2-[I-131]-iodo-N-acetyl-5-methoxy-tryptamine (2-[I-131]-iodo-melatonine) are described herein. These were synthesized by a high-yield novel method, and their spectral properties are fully described. These compounds are of biological importance and can be used for brain mapping with SPECT technology.
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页码：677 / 684
页数：8
相关论文
共 26 条
  • [1] ANGRIST S, 1976, PSYCHOPHARMACOLOGIA, V47, P29
  • [2] SYNTHESIS OF O-METHYLATED AND N-METHYLATED DERIVATIVES OF 5-HYDROXYTRYPTAMINE
    BENINGTON, F
    MORIN, RD
    CLARK, LC
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1958, 23 (12) : 1977 - 1979
  • [3] BIDDER TG, 1974, LANCET, V1, P165
  • [4] CHECKLEY SA, 1979, AM J PSYCHIAT, V136, P439
  • [5] IMPROVED FISCHER INDOLE REACTION FOR THE PREPARATION OF N,N-DIMETHYLTRYPTAMINES - SYNTHESIS OF L-695,894, A POTENT 5-HT1D RECEPTOR AGONIST
    CHEN, CY
    SENANAYAKE, CH
    BILL, TJ
    LARSEN, RD
    VERHOEVEN, TR
    REIDER, PJ
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (13) : 3738 - 3741
  • [6] GAS-LIQUID-CHROMATOGRAPHIC SEPARATION AND IDENTIFICATION OF BIOLOGICALLY IMPORTANT INDOLEALKYLAMINES FROM HUMAN CEREBROSPINAL FLUIDS
    CHRISTIAN, ST
    BENINGTON, F
    MORIN, RD
    CORBETT, L
    [J]. BIOCHEMICAL MEDICINE, 1975, 14 (02): : 191 - 200
  • [7] HALLUCINOGENIC N-METHYLATED INDOLE-ALKYLAMINES IN CEREBROSPINAL-FLUID OF PSYCHIATRIC AND CONTROL POPULATIONS
    CORBETT, L
    CHRISTIAN, ST
    MORIN, RD
    BENINGTON, F
    SMYTHIES, JR
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 1978, 132 (FEB) : 139 - 144
  • [8] NEW THEORY OF CEREBRAL AMINE FUNCTION AND ITS CLINICAL APPLICATION
    DEWHURST, WG
    [J]. NATURE, 1968, 218 (5147) : 1130 - &
  • [9] HARLEYMASON J, 1954, J AM CHEM SOC, V76, P1165
  • [10] HELLER B, 1970, J EXPT, V26, P503
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