The androgen receptor transcriptional program in castration-resistant prostate cancer

被引：2

作者：

Roth, Jeffrey E. ^{[1
]}

Peer, Cody J. ^{[1
]}

Price, Douglas K. ^{[1
]}

Figg, William D. ^{[1
]}

机构：

[1] NCI, Clin Pharmacol Program, Off Clin Director, Bethesda, MD 20892 USA

来源：

CANCER BIOLOGY & THERAPY | 2014年 / 15卷 / 01期

关键词：

androgen receptor; binding site; castration-resistant prostate cancer; transcription factor; transcriptional program; CELL-LINES; DISTINCT; PROGRESSION;

D O I：

10.4161/cbt.27149

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The androgen receptor (AR) is central to the initiation and progression of prostate cancer, even after castration. Its transcriptional activity has previously been studied in cell lines. A group at the University of Cambridge recently outlined the AR transcriptional program in tissue samples, with an emphasis on castration-resistant tumors. AR binding sites, gene-expression changes (in xenografts), and potential transcription factor interactions were notably different from those observed in cultured cells. These discrepancies suggest a distinct signaling network for the AR in vivo and serve as a reminder that results from in vitro models should be checked against clinical realities.

引用

页码：16 / 18

页数：3

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