Dysregulation of CDX1, CDX2 and SOX2 in patients with gastric cancer also affects the non-malignant mucosa

被引：18

作者：

Bornschein, Jan ^{[1
]}

Toth, Kinga ^{[2
]}

Selgrad, Michael ^{[1
]}

Kuester, Doerthe ^{[3
]}

Wex, Thomas ^{[1
,4
]}

Molnar, Bela ^{[2
,5
]}

Tulassay, Zsolt ^{[2
,5
]}

Malfertheiner, Peter ^{[1
]}

机构：

[1] Otto Von Guericke Univ, Dept Gastroenterol Hepatol & Infect Dis, D-39120 Magdeburg, Germany

[2] Semmelweis Univ, Dept Internal Med 2, H-1085 Budapest, Hungary

[3] Otto Von Guericke Univ, Dept Pathol, D-39120 Magdeburg, Germany

[4] Ctr Lab Med Microbiol & Infect Dis, Dept Mol Genet, Magdeburg, Germany

[5] Hungarian Acad Sci, Mol Med Res Unit, Budapest, Hungary

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2013年 / 66卷 / 09期

关键词：

GASTRIC CANCER; GASTRITIS; H PYLORI; HELICOBACTER PYLORI; MOLECULAR ONCOLOGY; INTESTINAL METAPLASIA; MOUSE STOMACH; EXPRESSION; PROGRESSION; MICE;

D O I：

10.1136/jclinpath-2013-201448

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The interplay between gastric and intestinal transcription factors has an important impact on gastric carcinogenesis. We compared the gene expression of CDX1, CDX2, SOX2 and related downstream genes in tumour and tumour surrounding gastric tissue of 48 gastric cancer patients with 30 healthy controls. There was no difference of gene expression of CDX1 and CDX2 between tumour or tumour-adjacent and tumour-distant mucosa, but both factors were significantly higher expressed in cancer patients compared with controls (p<0.01). SOX2 was downregulated in tumour tissue compared to controls, whereas tumour-adjacent and tumour-distant mucosa showed intermediate SOX2 expression. Lauren type and Helicobacter pylori infection had no significant impact on expression of the transcription factors. Expression of CDX1 and CDX2 was higher in the presence of intestinal metaplasia. The differential regulation of the gene expression of CDX1, CDX2 and SOX2 in patients with gastric cancer affects not only the tumour but also the non-neoplastic tumour-distant mucosa.

引用

页码：819 / 822

页数：4

共 12 条

[1] Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas [J].

Almeida, R ;

Silva, E ;

Santos-Silva, F ;

Silberg, DG ;

Wang, JF ;

De Bolós, C ;

David, L .

JOURNAL OF PATHOLOGY, 2003, 199 (01) :36-40

[2] H. pylori Infection Is a Key Risk Factor for Proximal Gastric Cancer [J].

Bornschein, Jan ;

Selgrad, Michael ;

Warnecke, Maren ;

Kuester, Doerthe ;

Wex, Thomas ;

Malfertheiner, Peter .

DIGESTIVE DISEASES AND SCIENCES, 2010, 55 (11) :3124-3131

[3] Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells [J].

Camilo, Vania ;

Barros, Rita ;

Sousa, Sofia ;

Magalhaes, Ana Maria ;

Lopes, Teresa ;

Santos, Antonio Mario ;

Pereira, Teresa ;

Figueiredo, Ceu ;

David, Leonor ;

Almeida, Raquel .

CARCINOGENESIS, 2012, 33 (10) :1985-1992

[4] Classification and grading of gastritis - The updated Sydney System [J].

Dixon, MF ;

Genta, RM ;

Yardley, JH ;

Correa, P ;

Batts, KP ;

Dahms, BB ;

Filipe, MI ;

Haggitt, RC ;

Haot, J ;

Hui, PK ;

Lechago, J ;

Lewin, K ;

Offerhaus, JA ;

Price, AB ;

Riddell, RH ;

Sipponen, P ;

Solcia, E ;

Watanabe, H .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (10) :1161-1181

[5] Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia [J].

Eda, A ;

Osawa, H ;

Yanaka, I ;

Satoh, K ;

Mutoh, H ;

Kihira, K ;

Sugano, K .

JOURNAL OF GASTROENTEROLOGY, 2002, 37 (02) :94-100

[6] Development of gastric carcinoma from intestinal metaplasia in CDx2-transgenic mice [J].

Mutoh, H ;

Sakurai, S ;

Satoh, K ;

Tamada, K ;

Kita, H ;

Osawa, H ;

Tomiyama, T ;

Sato, Y ;

Yamamoto, H ;

Isoda, N ;

Yoshida, T ;

Ido, K ;

Sugano, K .

CANCER RESEARCH, 2004, 64 (21) :7740-7747

[7] Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice [J].

Mutoh, H ;

Sakurai, S ;

Satoh, K ;

Osawa, H ;

Hakamata, Y ;

Takeuchi, T ;

Sugano, K .

GUT, 2004, 53 (10) :1416-1423

[8] Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa [J].

Mutoh, Hiroyuki ;

Sashikawa, Miho ;

Sugano, Kentaro .

DIFFERENTIATION, 2011, 81 (02) :92-98

[9] Transgenic Cdx2 induces endogenous Cdx1 in intestinal metaplasia of Cdx2-transgenic mouse stomach [J].

Mutoh, Hiroyuki ;

Hayakawa, Hiroko ;

Sakamoto, Hirotsugu ;

Sashikawa, Miho ;

Sugano, Kentaro .

FEBS JOURNAL, 2009, 276 (20) :5821-5831

[10] Association between environmental factors and CDX2 expression in gastric cancer patients [J].

Peleteiro, Barbara ;

Lunet, Nuno ;

Wen, Xiaogang ;

Afonso, Luis Pedro ;

Mendes, Nuno ;

Barros, Rita ;

Carneiro, Fatima ;

Almeida, Raquel ;

Barros, Henrique .

EUROPEAN JOURNAL OF CANCER PREVENTION, 2012, 21 (05) :423-431

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