Role of haem oxygenase-1 in microbial host defence

被引：86

作者：

Chung, Su Wol ^{[1
,2
]}

Hall, Sean R. ^{[2
]}

Perrella, Mark A. ^{[2
]}

机构：

[1] Univ Ulsan, Coll Nat Sci, Dept Sci Biol, Ulsan 680749, South Korea

[2] Brigham & Womens Hosp, Dept Med, Div Pulm & Crit Care Med, Boston, MA 02115 USA

来源：

CELLULAR MICROBIOLOGY | 2009年 / 11卷 / 02期

基金：

美国国家卫生研究院;

关键词：

HEPATITIS-B-VIRUS; CARBON-MONOXIDE; MYCOBACTERIUM-TUBERCULOSIS; OXIDATIVE STRESS; GENE-EXPRESSION; IN-VIVO; SEPSIS; PATHOGENESIS; SARCOMA; BACH1;

D O I：

10.1111/j.1462-5822.2008.01261.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Haem oxygenase (HO)-1 is a cytoprotective enzyme that plays a critical role in defending the body against oxidant-induced injury during inflammatory processes. HO catalydes the degradation of haem to carbon monoxide (CO), biliverdin and ferrous iron. Biliverdin is converted to bilirubin, a potent endogenous antioxidant. CO has a number of biological functions, including anti-inflammatory properties. In various models of disease, HO-1 is known to play a critical role by ameliorating the pathological consequences of injury. In many of these models, the beneficial effects of HO-1 and its products of haem catabolism are by suppressing an inflammatory response. However, when investigating diseases due to microbial infections, inhibition of the inflammatory response could disrupt the ability of the immune system to eradicate an invading pathogen. Thus, questions remain regarding the role of HO-1 in microbial host defence. This microreview will address our present understanding of HO-1 and its functional significance in a variety of microbial infections.

引用

页码：199 / 207

页数：9

共 69 条

[21] Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice [J].

Hashiba, T ;

Suzuki, M ;

Nagashima, Y ;

Suzuki, S ;

Inoue, S ;

Tsubarai, T ;

Matsuses, T ;

Ishigatubo, Y .

GENE THERAPY, 2001, 8 (19) :1499-1507

[22] Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1 [J].

Hou, Welhong ;

Shan, Ying ;

Zheng, Jianyu ;

Larnbrecht, Richard W. ;

Donohue, Susan E. ;

Bonkovsky, Herbert L. .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2008, 1779 (03) :195-203

[23] A critical role for OX40 in T cell-mediated immunopathology during lung viral infection [J].

Humphreys, IR ;

Walzl, G ;

Edwards, L ;

Rae, A ;

Hill, S ;

Hussell, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (08) :1237-1242

[24] Early expression of heme oxygenase-1 in leukocytes correlates negatively with oxidative stress and predicts hepatic and renal dysfunction at late stage of sepsis [J].

Jao, HC ;

Lin, YT ;

Tsai, LY ;

Wang, CC ;

Liu, HW ;

Hsu, C .

SHOCK, 2005, 23 (05) :464-469

[25] Pro-oxidant and cytotoxic effects of circulating heme [J].

Jeney, V ;

Balla, J ;

Yachie, A ;

Varga, Z ;

Vercellotti, GM ;

Eaton, JW ;

Balla, G .

BLOOD, 2002, 100 (03) :879-887

[26] Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA [J].

Jopling, CL ;

Yi, MK ;

Lancaster, AM ;

Lemon, SM ;

Sarnow, P .

SCIENCE, 2005, 309 (5740) :1577-1581

[27] Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon [J].

Kumar, Ashwani ;

Deshane, Jessy S. ;

Crossman, David K. ;

Bolisetty, Subhashini ;

Yan, Bo-Shiun ;

Kramnik, Igor ;

Agarwal, Anupam ;

Steyn, Adrie J. C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (26) :18032-18039

[28] Characterization of the mouse aortic carboxypeptidase-like protein promoter reveals activity in differentiated and dedifferentiated vascular smooth muscle cells [J].

Layne, MD ;

Yet, SF ;

Maemura, K ;

Hsieh, CM ;

Liu, XL ;

Ith, B ;

Lee, ME ;

Perrella, MA .

CIRCULATION RESEARCH, 2002, 90 (06) :728-736

[29] 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference [J].

Levy, MM ;

Fink, MP ;

Marshall, JC ;

Abraham, E ;

Angus, D ;

Cook, D ;

Cohen, J ;

Opal, SM ;

Vincent, JL ;

Ramsay, G .

CRITICAL CARE MEDICINE, 2003, 31 (04) :1250-1256

[30] 30 some years of heme oxygenase:: From a "molecular wrecking ball" to a "mesmerizing" trigger of cellular events [J].

Maines, MD ;

Gibbs, PEM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 338 (01) :568-577

← 1 2 3 4 5 6 7 →